Proteus mirabilis is one of the important etiologic agents of urinary tract infections (UTI), which complicates the long-term urinary catheterization process in clinical settings. Owing to its crystalline biofilm forming ability and flagellar motility, elimination of P. mirabilis from urinary system becomes very difficult. Thus, the present study is focused to prepare antibiofilm-impregnated Silicone Foley Catheter (SFC) to prevent P. mirabilis instigated UTIs. Through solvent swelling method, the antibiofilm compounds such as linalool (LIN) and 2-hydroxy-4-methoxy benzaldehyde (HMB) were successfully infused into SFCs. Surface topography was studied using AFM analysis, which unveiled the unmodified surface roughness of normal and antibiofilm-impregnated SFCs. In addition, UV-spectrometric and FT-IR analyses revealed good impregnation efficacy and prolonged stability of antibiofilm compounds. Further, in vitro biofilm biomass quantification assay exhibited a maximum of 87 % and 84 % crystalline biofilm inhibition in LIN (350 μg/cm³) and HMB (120 μg/cm³) impregnated SFCs, respectively against P. mirabilis in artificial urine medium. Also, the LIN & HMB-impregnated SFCs demonstrated long-term crystalline biofilm inhibitory activity for more than 30 days, which is ascribed to the sustained release of the compounds. Furthermore, the results of swarming motility analysis revealed the efficacy of antibiofilm-impregnated catheters to mitigate the migration of pathogens over them. Thus, antibiofilm-impregnated catheter is proposed to act as a suitable strategy for reducing P. mirabilis infections and associated complications in long-term urinary catheter users.

奇异变形杆菌是尿路感染（UTI）的重要病因之一，在临床环境中使长期的导尿管插入过程变得复杂。由于其结晶生物膜形成能力和鞭毛运动性，从泌尿系统中消除奇异假单胞菌变得非常困难。因此，本研究着重于制备抗生物膜浸渍的有机硅Foley导管（SFC），以预防奇异疟原虫煽动性的UTI。通过溶剂溶胀法，将芳樟醇（LIN）和2-羟基-4-甲氧基苯甲醛（HMB）等抗生物膜化合物成功注入SFC中。使用AFM分析研究了表面形貌，该分析揭示了普通和浸有生物膜的SFC的未改性表面粗糙度。此外，紫外光谱和FT-IR分析表明抗生物膜化合物具有良好的浸渍效果和较长的稳定性。此外，体外生物膜生物量定量测定分别在浸渍了LIN（350μg/ cm ³）和HMB（120μg/ cm ³）的SFC中分别显示了87％和84％的结晶生物膜抑制作用，分别针对拟南芥在人造尿液中 同样，LIN和HMB浸渍的SFC表现出超过30天的长期结晶生物膜抑制活性，这归因于化合物的持续释放。此外，群体运动分析的结果显示了抗生物膜浸渍导管减轻病原体在其上迁移的功效。因此，提出了用抗生物膜浸渍的导管作为减少长期导尿管使用者中奇异假单胞菌感染和相关并发症的合适策略。