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Superhydrophilic fluorinated polymer and nanogel for high-performance 19F magnetic resonance imaging.
Biomaterials ( IF 14.0 ) Pub Date : 2020-06-17 , DOI: 10.1016/j.biomaterials.2020.120184
Zujian Feng 1 , Qinghua Li 1 , Weiwei Wang 2 , Qiankun Ni 3 , Yufei Wang 3 , Huijuan Song 2 , Chuangnian Zhang 2 , Deling Kong 4 , Xing-Jie Liang 3 , Pingsheng Huang 2
Affiliation  

19F magnetic resonance imaging (19F MRI), a kind of non-invasive and non-radioactive diagnostic technique with no endogenous background signals, opens up new research avenues for accurate molecular imaging studies. However, 19F MRI is manily limited by the performance of contrast agents. Here, for the first time, we presented the zwitterionic fluorinated polymer and nanogel as new types of superhydrophilic, sensitive and ultra-stable 19F MRI contrast agents. The superhydrophilicity of carboxybetaine zwitterionic structure completely overcame the hydrophobic aggregation-induced signal attenuation associated with amphiphilic fluorinated polymer-based nanoprobes. In addition, the superhydrophilic contrast agent exhibited distinct advantages, including high 19F-content (19.1 wt%), superior resistance to protein adsorption, constant MR properties and 19F MRS-based quantitative determination in complex biological fluids, and intense 19F MRI signals in the whole-body images after intravenous injection. In combination with angiogenesis targeting ligand, the superhydrophilic contrast agent was applied for the unambiguous detection of tumor. Importantly, computational algorithm was established for the directly quantitative determination of bioavailability and tumor-to-whole body ratio (TBR) from the in vivo 19F MRI dataset, providing real-time information with non-invasive manner. Finally, crosslinked nanogels were developed with significantly prolonged systemic circulation, of which intense 19F MRI signals nonspecifically distributed in the aortaventralis and blood-rich organs, instead of being trapped steadily in liver as with the state-of-the-art superhydrophobic perfluocarbon nanoemulsions. Overall, this kind of superhydrophilic, zwitterionic fluorinated polymer and nanogel could be defined as a new generation of high-performance 19F MRI contrast agents, which hold great potential for image-based unambiguous disease detection and computational quantification.



中文翻译:

超亲水性氟化聚合物和纳米凝胶,用于高性能19F磁共振成像。

19 F磁共振成像(19 F MRI)是一种无内源性,无内在信号的诊断技术,为准确的分子成像研究开辟了新的研究途径。但是,19 F MRI受造影剂性能的限制。在这里,我们首次展示了两性离子氟化聚合物和纳米凝胶,它们是新型的超亲水,敏感和超稳定的19。F MRI造影剂。羧基甜菜碱两性离子结构的超亲水性完全克服了与两亲氟化聚合物基纳米探针相关的疏水性聚集诱导的信号衰减。此外,超亲水性造影剂还显示出独特的优势,包括19 F含量高(19.1 wt%),对蛋白质吸附的优越抵抗力,恒定的MR特性和在复杂生物流体中基于19 F MRS的定量测定,以及19静脉注射后全身图像中的F MRI信号。与靶向血管生成的配体结合,将超亲水性造影剂用于肿瘤的明确检测。重要的是,建立了用于从体内19 F MRI数据集直接定量确定生物利用度和肿瘤与全身比(TBR)的计算算法,以无创方式提供实时信息。最后,开发了具有显着延长的系统循环的交联纳米凝胶,其中强烈的19 F MRI信号非特异性地分布在主动脉和血液丰富的器官中,而不是像最新的超疏水全氟碳纳米乳剂一样被稳定地捕获在肝脏中。总体而言,这种超亲水性,两性离子氟化聚合物和纳米凝胶可被定义为新一代高性能19 F MRI造影剂,它们在基于图像的明确疾病检测和计算量化方面具有巨大潜力。

更新日期:2020-06-25
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