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Two-dimensional silicene composite nanosheets enable exogenous/endogenous-responsive and synergistic hyperthermia-augmented catalytic tumor theranostics.
Biomaterials ( IF 14.0 ) Pub Date : 2020-06-17 , DOI: 10.1016/j.biomaterials.2020.120206
Huican Duan 1 , Haiyan Guo 1 , Ruifang Zhang 1 , Fangfang Wang 1 , Zhuang Liu 2 , Min Ge 3 , Luodan Yu 3 , Han Lin 3 , Yu Chen 3
Affiliation  

Silicene as an emerging two-dimensional material (2DM) spurs the broad research interests due to its prominent electronic and physical properties, however, still lacking in exploitation for the biological and medical practices. Herein, we constructed a 2D silicene-based theranostic nanoplatform, MnOx@silicene-BSA (MS-BSA), with tumor microenvironment (TME)-responsive and synergistic hyperthermia-augmented catalytic activity when irradiated by near infrared-II (NIR-II) laser because of the high photothermal-conversion efficiency of 2D silicene matrix. Such MS-BSA nanosheets possess the capability to react with glutathione (GSH) to generate Mn2+ and glutathione disulfide (GSSG) under acidity/reducing TME condition. With the presence/assistance of HCO3, the released Mn2+ exhibited sensitive catalytic activity towards endogenous H2O2 via Fenton-like reaction, enabling the generation of highly toxic hydroxyl radicals (•OH), which finally led to the enhanced nanocatalytic therapeutic efficacy followed by exogenous NIR-II laser exposure, originating from hyperthermia-augmented catalytic activity. Especially, these MS-BSA nanosheets accumulated into the tumor region to enable superb contrast enhancement of TME-responsive T1-weighted magnetic resonance imaging (MRI) and photoacoustic imaging (PAI), and high-efficient in vivo synergistic tumor eradication. Therefore, such an intelligent photothermal-enhanced catalytic theranostic nanoplatform could realize the exogenous/endogenous-responsive and cooperative hyperthermia-augmented tumor treatment and accurate tumor positioning/monitoring.



中文翻译:

二维硅树脂复合纳米片可实现外源性/内源性响应和协同高热增强催化肿瘤治疗。

硅作为新兴的二维材料(2DM),由于其突出的电子和物理特性而引起了广泛的研究兴趣,然而,仍然缺乏对生物学和医学实践的利用。在这里,我们构建了一种二维的基于硅碳氢化合物的氧化硅纳米平台,MnO x @硅碳-BSA(MS-BSA),当被近红外-II(NIR-II)照射时,具有肿瘤微环境(TME)响应和协同高热增强的催化活性。 )激光是因为2D硅基质具有很高的光热转换效率。这种MS-BSA纳米片具有在酸性/还原TME条件下与谷胱甘肽(GSH)反应生成Mn 2+和谷胱甘肽二硫化物(GSSG)的能力。在HCO 3存在/协助下-,释放的Mn 2+通过Fenton样反应对内源H 2 O 2 表现出敏感的催化活性,从而能够产生高毒性的羟基自由基(•OH),最终导致增强的纳米催化治疗功效,随后是外源性NIR-II激光照射,源自热疗增强的催化活性。尤其是,这些MS-BSA纳米片积聚到肿瘤区域中,从而能够出色增强TME响应性T 1加权磁共振成像(MRI)和光声成像(PAI)的对比度,并在体内产生高效的效果协同消灭肿瘤。因此,这种智能的光热增强催化治疗药物纳米平台可以实现外源性/内源性反应性和协同性高热增强的肿瘤治疗,并能精确地定位/监测肿瘤。

更新日期:2020-06-27
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