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A review of solitary fibrous tumor/hemangiopericytoma tumor and a comparison of risk factors for recurrence, metastases, and death among patients with spinal and intracranial tumors.
Neurosurgical Review ( IF 2.8 ) Pub Date : 2020-06-18 , DOI: 10.1007/s10143-020-01335-x
Enrico Giordan 1 , Elisabetta Marton 2 , Alexandra M Wennberg 3 , Angela Guerriero 4 , Giuseppe Canova 1
Affiliation  

Meningeal solitary fibrous tumors (SFTs) and hemangiopericytomas (HPCs) had been combined into a single classification until 2016. Recurrence and metastases rates are still understudied, especially for spinal SFT/HPCs. Here, we describe CNS SFT/HPCs and predictors for recurrence, metastases, and death, in spinal and intracranial SFT/HPCs, separately. We collected data from studies with patient-level data available on primary SFT/HPCs from multiple online databases. Clinico-demographic data, surgical outcomes, recurrence, metastases, and death rates were abstracted. We used logistic and Cox regression models to identify predictors for recurrence, metastases, and death for spinal and intracranial SFT/HPCs. Twenty-nine studies (368 patients) were included. Higher histological grade and subtotal resection were associated with recurrence (p values < 0.05), while higher histological grade and recurrence (p values < 0.005) were associated with metastases formation. Time to recurrence (p < 0.005) and metastases (p < 0.001) formation were shorter for spinal SFT/HPCs. Death rates were higher among intracranial SFT/HPC patients (p value = 0.001). Among patients with higher histological grade, rates of metastases formation were different between intracranial and spinal SFT/HPCs. Risk of metastases was higher in the first 5 years from surgery for both intracranial and spinal SFT/HPCs. Meningeal SFT/HPCs patients have high rates of recurrence and metastasis, which occur mostly within the first 5 years after diagnosis. Spinal and intracranial SFT/HPCs show similar behavior, but spinal SFT/HPCs tend to develop metastases and recurrences in a shorter interval of time. Careful follow-up for spinal SFT/HPCs should be considered because spinal cases seem to be slightly more aggressive and require more attention.



中文翻译:

回顾性孤立性纤维性肿瘤/血运细胞瘤肿瘤以及脊柱和颅内肿瘤患者复发,转移和死亡的危险因素比较。

脑膜孤立性纤维性肿瘤(SFT)和血管内皮细胞瘤(HPC)已合并为单一分类,直到2016年。仍未充分研究其复发和转移率,尤其是对于脊柱SFT / HPC。在这里,我们分别描述了中枢神经系统SFT / HPC和脊髓,颅内SFT / HPC中复发,转移和死亡的预测因子。我们从研究中收集了数据,并从多个在线数据库中获得了有关主要SFT / HPC的患者水平的数据。临床人口统计学数据,手术结局,复发,转移和死亡率均被提取。我们使用逻辑和Cox回归模型来确定脊柱和颅内SFT / HPC的复发,转移和死亡的预测因子。包括29项研究(368例患者)。较高的组织学分级和次全切除与复发相关(p值<0.05),而较高的组织学分级和复发率(p值<0.005)与转移形成有关。 脊柱SFT / HPCs的复发时间(p  <0.005)和转移灶(p <0.001)较短。颅内SFT / HPC患者的死亡率较高(p值= 0.001)。在具有较高组织学等级的患者中,颅内和脊髓SFT / HPC之间的转移形成率不同。颅内和脊柱SFT / HPCs手术后头5年的转移风险较高。脑膜SFT / HPCs患者的复发和转移率很高,主要发生在诊断后的前5年内。脊柱和颅内SFT / HPCs表现出相似的行为,但脊柱SFT / HPCs倾向于在较短的时间间隔内发生转移和复发。应考虑对脊柱SFT / HPC进行仔细随访,因为脊柱病例似乎更具侵略性,需要更多关注。

更新日期:2020-06-18
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