Background Understanding ischemic stroke pathogenesis helps in prevention, prognosis, and treatment. Stroke is greatly related to inflammation and thrombo-genesis as inflammatory cells (as neutrophils-lymphocytes) and thrombo-genic agents as von Willebrand factor antigen (VWF: Ag) and epicardial fat. Objectives of the study Evaluation of epicardial fat thickness (EFT), neutrophil/lymphocytic ratio (NLR), and (VWF: Ag) levels as predisposing and prognostic factors of ischemic stroke. Patients and methods Sixty acute ischemic stroke patients were subjected to clinical assessment (Oxford stroke sheet), National Institute Health Stroke Scale: NIHSS), Modified Rankin Scale (MRS), NLR and VWF: Ag levels, transthoracic echo, duplex on carotid and vertebro-basilar arteries, and brain computed tomography (CT). Thirty-five healthy controls matched for age and sex were subjected to the same steps except NIHSS and MRS. Results EFT, NLR, and VWF among patients were significantly higher than control group. NLR ≥ 2 and VWF: Ag were significant risk factors among stroke patients with VWF: Ag had the higher risk than NLR ≥ 2. NLR was a high valid prognostic marker in predicting stroke outcome (MRS) with (optimal cutoff value 2.05) for prediction of primary unfavorable outcome. There was no statistical significance between (MRS) and EFT or VWF: Ag level. Conclusion EFT represents inexpensive and readily available clinical marker that may be useful in estimating risk of ischemic stroke. NLR is non-expensive easy marker for predicting stroke severity and primary unfavorable outcome. High VWF level increases ischemic stroke risk.

中文翻译：

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新的卒中预后因素

背景 了解缺血性中风的发病机制有助于预防、预后和治疗。中风与炎症和血栓形成密切相关，如炎症细胞（如中性粒细胞 - 淋巴细胞）和血栓形成因子，如血管性血友病因子抗原（VWF：Ag）和心外膜脂肪。研究目的 评估心外膜脂肪厚度 (EFT)、中性粒细胞/淋巴细胞比率 (NLR) 和 (VWF: Ag) 水平作为缺血性中风的易感和预后因素。患者和方法 60 名急性缺血性卒中患者接受临床评估（牛津卒中表）、美国国立卫生研究院健康卒中量表：NIHSS）、改良 Rankin 量表（MRS）、NLR 和 VWF：Ag 水平、经胸回声、颈动脉和椎体双工- 基底动脉和脑计算机断层扫描 (CT)。除了 NIHSS 和 MRS 之外，35 名年龄和性别匹配的健康对照接受了相同的步骤。结果患者的EFT、NLR、VWF均显着高于对照组。NLR ≥ 2 和 VWF：Ag 是 VWF 卒中患者的显着危险因素：Ag 的风险高于 NLR ≥ 2。NLR 是预测卒中结果 (MRS) 的高有效预后标志物，具有（最佳截止值 2.05）预测的主要不利结果。(MRS) 和 EFT 或 VWF: Ag 水平之间没有统计学意义。结论 EFT 是一种廉价且容易获得的临床标志物，可用于估计缺血性中风的风险。NLR 是预测中风严重程度和主要不利结果的非昂贵的简单标记。高 VWF 水平会增加缺血性中风的风险。