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RETRACTED: Association Between Polymorphisms in the Interleukin-10 Gene and Susceptibility to HIV-1 Infection.
AIDS Research and Human Retroviruses ( IF 1.5 ) Pub Date : 2020-06-16 , DOI: 10.1089/aid.2020.0011
Dan-Hui Fu 1 , Wen-Juan Deng 1 , Zhi Yang 2 , Sen Hong 1 , Qian-Ling Ding 1 , Yang Zhao 1 , Jia Chen 1 , Dan-Ke Su 3
Affiliation  

ackground: This study meta-analyzed the literature on possible association of three polymorphisms (-592, -1082, -819) in the interleukin-10 (IL-10) gene with susceptibility to HIV-1 infection. Methods: PubMed, EMBASE, MEDLINE and Google Scholar were systematically searched to identify relevant studies in English. Meta-analyses were performed to examine the association of IL-10 polymorphisms -592, -1082, and -819 with susceptibility to HIV-1 infection. Results: A significant association between the -592 polymorphism and susceptibility to HIV-1 infection was found in the total population (recessive model, OR = 1.44, 95% CI = 1.06-1.96, P = 0.02; homozygous model, OR = 1.44, 95% CI = 1.02-2.02, P = 0.04). However, these results were not observed in subgroups based on ethnicity. The -1082 polymorphism was significantly associated with susceptibility to HIV-1 infection in Caucasians (OR = 1.30, 95% CI = 1.05-1.62, P = 0.02; recessive model, OR = 1.49, 95% CI = 1.09-2.03, P = 0.01; homozygous model, OR = 1.58, 95% CI = 1.01-2.46, P = 0.04), but not in Asians or the total population. None of the five genetic models suggested a significant association between the -819 polymorphism and HIV-1 infection. Conclusion: The available evidence indicates that the AA genotype of IL-10 -592 may confer increased susceptibility to HIV-1 infection, and that the AA genotype of -1082 may confer increased susceptibility in Caucasians. In contrast, the -819 polymorphism may not be associated with HIV-1 infection risk. These conclusions should be verified in large, well-designed studies.

中文翻译:

缩回:白介素10基因多态性与HIV-1感染易感性之间的关联。

背景:这项研究荟萃分析了IL-10(IL-10)基因中三种多态性(-592,-1082,-819)与HIV-1感染易感性的关联的文献。方法:系统地搜索PubMed,EMBASE,MEDLINE和Google Scholar,以鉴定相关的英语研究。进行荟萃分析以检查IL-10多态性-592,-1082和-819与HIV-1感染易感性的关系。结果:在总人群中发现-592基因多态性与HIV-1感染易感性之间存在显着相关性(隐性模型,OR = 1.44,95%CI = 1.06-1.96,P = 0.02;纯合模型,OR = 1.44, 95%CI = 1.02-2.02,P = 0.04)。但是,在基于种族的亚组中未观察到这些结果。-1082多态性与白种人的HIV-1感染易感性显着相关(OR = 1.30,95%CI = 1.05-1.62,P = 0.02;隐性模型,OR = 1.49,95%CI = 1.09-2.03,P = 0.01;纯合子模型,OR = 1.58,95%CI = 1.01-2.46,P = 0.04),但不适用于亚洲人或总人口。五个遗传模型均未显示-819多态性与HIV-1感染之间存在显着关联。结论:现有证据表明,IL-10 -592的AA基因型可能增加对HIV-1感染的易感性,而-1082的AA基因型可能导致高加索人的易感性增加。相反,-819基因多态性可能与HIV-1感染风险无关。这些结论应在设计合理的大型研究中得到验证。05-1.62,P = 0.02;隐性模型,OR = 1.49,95%CI = 1.09-2.03,P = 0.01; 纯合子模型,OR = 1.58,95%CI = 1.01-2.46,P = 0.04),但不适用于亚洲人或总人口。五个遗传模型均未显示-819多态性与HIV-1感染之间存在显着关联。结论:现有证据表明,IL-10 -592的AA基因型可能增加对HIV-1感染的易感性,而-1082的AA基因型可能导致高加索人的易感性增加。相反,-819基因多态性可能与HIV-1感染风险无关。这些结论应在设计合理的大型研究中得到验证。05-1.62,P = 0.02;隐性模型,OR = 1.49,95%CI = 1.09-2.03,P = 0.01; 纯合子模型,OR = 1.58,95%CI = 1.01-2.46,P = 0.04),但不适用于亚洲人或总人口。五个遗传模型均未显示-819多态性与HIV-1感染之间存在显着关联。结论:现有证据表明,IL-10 -592的AA基因型可能增加对HIV-1感染的易感性,而-1082的AA基因型可能导致高加索人的易感性增加。相反,-819基因多态性可能与HIV-1感染风险无关。这些结论应在设计合理的大型研究中得到验证。五个遗传模型均未显示-819多态性与HIV-1感染之间存在显着关联。结论:现有证据表明,IL-10 -592的AA基因型可能增加对HIV-1感染的易感性,而-1082的AA基因型可能导致高加索人的易感性增加。相反,-819基因多态性可能与HIV-1感染风险无关。这些结论应在设计合理的大型研究中得到验证。五个遗传模型均未显示-819多态性与HIV-1感染之间存在显着关联。结论:现有证据表明,IL-10 -592的AA基因型可能增加对HIV-1感染的易感性,而-1082的AA基因型可能导致高加索人的易感性增加。相反,-819基因多态性可能与HIV-1感染风险无关。这些结论应在设计合理的大型研究中得到验证。-819基因多态性可能与HIV-1感染风险无关。这些结论应在设计合理的大型研究中得到验证。-819基因多态性可能与HIV-1感染风险无关。这些结论应在设计合理的大型研究中得到验证。
更新日期:2020-06-16
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