Introduction

Despite significant advances in treatment and prevention of HIV-1 infection, poor adherence to daily combination antiretroviral therapy (ART) regimens remains a major obstacle toward achieving sustained viral suppression and prevention. Adherence to ART could also be compromised by adverse drug reactions and societal factors that limit access to therapy. Therefore, medicines that aim to improve adherence by limiting ART side effects, frequency of dosing and socially acceptable regimens are becoming more attractive.

Areas covered

This review highlights recent advances and challenges in the development of long-acting drug delivery strategies for HIV prevention and treatment. Approaches for extended oral and transdermal deliveries, microbicides, broadly neutralizing antibodies, and long-acting implantable and injectable deliveries are reviewed.

Expert opinion

Emerging approaches on long-acting antiretroviral therapies and broadly neutralizing antibody technologies are currently at various stages of development. Such efforts, if successful and become broadly accepted by clinicians and users, will provide newer and simpler options for prevention and treatment of HIV infection.

中文翻译：

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用于预防和治疗 HIV 的抗逆转录病毒药物输送的长效方法：近期研究综述。

介绍

尽管在治疗和预防 HIV-1 感染方面取得了重大进展，但对每日联合抗逆转录病毒治疗 (ART) 方案的依从性差仍然是实现持续病毒抑制和预防的主要障碍。对 ART 的依从性也可能受到药物不良反应和限制获得治疗的社会因素的影响。因此，旨在通过限制 ART 副作用、给药频率和社会可接受的方案来提高依从性的药物正变得越来越有吸引力。

涵盖的领域

本综述重点介绍了在制定用于艾滋病预防和治疗的长效给药策略方面的最新进展和挑战。综述了延长口服和经皮给药、杀微生物剂、广泛中和抗体以及长效植入和注射给药的方法。

专家意见

长效抗逆转录病毒疗法和广泛中和抗体技术的新兴方法目前处于不同的发展阶段。如果这些努力成功并被临床医生和用户广泛接受，将为预防和治疗 HIV 感染提供更新和更简单的选择。