ABSTRACT

A key feature of macroautophagy (hereafter autophagy) is the formation of the phagophore, a double-membrane compartment sequestering cargos and finally maturing into a vesicle termed an autophagosome; however, where these membranes originate from is not clear. In a previous study, researchers from the Rubinsztein lab proposed a model in which the autophagosome can evolve from the RAB11A-positive recycling endosome. In their recent paper, they determine that DNM2 (dynamin 2) functions in scission of the recycling endosome, and the release of the autophagosome precursor. These findings explain how the centronuclear myopathy (CNM) mutation in DNM2 results in the accumulation of immature autophagic structures.

摘要

巨噬细胞自噬（以下称为自噬）的一个关键特征是吞噬细胞的形成，它是一个双膜隔室，隔离货物并最终成熟为称为自噬体的囊泡。但是，这些膜的来源尚不清楚。在先前的研究中，来自鲁宾斯汀实验室的研究人员提出了一种模型，其中自噬体可以从RAB11A阳性回收内体进化而来。在他们最近的论文中，他们确定DNM2（动力蛋白2）在切断回收内体​​和自噬体前体的释放中起作用。这些发现解释了DNM2中的中心核肌病（CNM）突变如何导致未成熟的自噬结构的积累。