Introduction: House dust mite contains several allergen components and causes perennial allergy. Lately, a new major allergen, Der p 23, was described with relatively high sensitization rates in different European Countries. In addition, Der p 23 is supposed to cause asthmatic disease. Objective: We would like to question the prevalence and clinical impact of specific immunoglobulin E to Der p 23 in a large patient sample in southern Bavaria, Germany. Methods: 474 patients from southern Bavaria, who visited the allergy department within the Department of Oto-Rhino-Laryngology of a university hospital, with sensitization to Dermatophagoides pteronyssinus were retrospectively compared regarding their sensitization profile to Der p 1, Der p 2, and Der p 23 and their clinical characteristics. Results: Among D. pteronyssinus-sensitized patients, the overall sensitization rate to Der p 23 was 42% in southern Bavaria. Most likely, patients were simultaneously sensitized to Der p 1, Der p 2, and Der p 23. Der p 23-sensitized patients reported more frequently asthma and showed higher prevalence of poly-sensitization towards 3 additional allergen groups and higher prevalence of double-sensitization to Der p 1 and Der p 2 compared to patients with missing sensitization to Der p 23. Considering the results of allergen provocation tests, neither IgE sensitization against Der p 23 nor levels of specific immunoglobulin E to Der p 23 allow a clear prediction of the clinical relevance of the sensitization. Conclusion: With a sensitization rate of 42%, Der p 23 closely misses the criterion of a major allergen in our southern Bavarian patient collective. A higher prevalence of polysensitization and self-reported asthma was the only clinical feature found in Der p 23-sensitized patients.
Int Arch Allergy Immunol

中文翻译：

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Der p 23致敏作用：对474名螨虫敏感患者的分析。

简介：屋尘螨含有多种过敏原成分，会引起多年生过敏。最近，在不同的欧洲国家描述了一种新的主​​要过敏原Der p 23，其致敏率相对较高。另外，Der p 23被认为会引起哮喘。目的：我们想对德国南部巴伐利亚州大量患者样本中特异性免疫球蛋白E对Der p 23的患病率及其临床影响提出质疑。方法：从巴伐利亚南部的474例患者，谁访问了一所大学医院的门Oto-犀牛，喉科部内的过敏部门，与致敏屋尘螨回顾性地比较了它们对Der p 1，Der p 2和Der p 23的敏感性及其临床特征。结果：在蕨类植物中致敏患者，巴伐利亚南部对Der p 23的总体致敏率为42％。患者最有可能同时对Der p 1，Der p 2和Der p 23致敏。Derp 23致敏的患者报告哮喘更为频繁，并且对3个其他变应原组的多重致敏率更高，而双敏的致敏率更高。对Der p 1和Der p 2的致敏性与缺少对Der p 23的致敏性的患者相比。考虑到过敏原激发试验的结果，针对Der p 23的IgE致敏性和对Der p 23的特异性免疫球蛋白E的水平均不能明确预测致敏的临床意义。结论：Der p 23的致敏率为42％，完全错过了我们巴伐利亚南部患者群体中主要致敏原的标准。在Der p 23致敏患者中，多敏化和自报告性哮喘的患病率较高是唯一的临床特征。
Int Arch过敏免疫