Background: Pathophysiology mechanism of primary focal hyperhidrosis (PFHH) is controversial. Heart rate variability (HRV) could explain if there is a systemic component present. We aimed to investigate the functions of the autonomic nervous system in patients diagnosed with PFHH compared to controls using the analysis of HRV in the domains of time, frequency, and nonlinearity, as well as analysis of the recurrence plots (RPs). Methods: We selected 34 patients with PFHH (29.4 ± 10.2 years) and 34 controls (29.2 ± 9.6 years) for HRV analysis. Heart beats were recorded with Polar RS800CX monitor (20 min, at rest, in supine position), and RR intervals were analyzed with Kubios Premium HRV software. RPs were constructed with Visual Recurrence Analysis software. Statistical analysis included unpaired t test (p < 0.05). Results: Our results showed that HRV parameters in the 3 domains evaluated did not show any differences between the groups. The same was observed with RPs. Conclusions: The findings suggest that PFHH, from the pathophysiological point of view, may be caused by peripheral involvement of the sympathetic nervous system (glandular level or nerve terminals), as there was no difference between the groups studied. More specific studies should help elucidate this issue.

中文翻译：

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心率变异性评估及其在多汗症患者自主神经功能评估中的应用

背景：原发性局灶性多汗症（PFHH）的病理生理机制存在争议。心率变异性 (HRV) 可以解释是否存在全身性成分。我们旨在使用时间、频率和非线性域中的 HRV 分析以及复发图 (RP) 分析来研究诊断为 PFHH 的患者与对照组相比自主神经系统的功能。方法：我们选择了 34 名 PFHH 患者（29.4 ± 10.2 岁）和 34 名对照（29.2 ± 9.6 岁）进行 HRV 分析。使用 Polar RS800CX 监测器记录心跳（20 分钟，休息时，仰卧位），并使用 Kubios Premium HRV 软件分析 RR 间期。RPs 是用 Visual Recurrence Analysis 软件构建的。统计分析包括未配对 t 检验（p < 0.05）。结果：我们的结果表明，评估的 3 个领域中的 HRV 参数在组之间没有显示任何差异。使用RP观察到同样的情况。结论：研究结果表明，从病理生理学的角度来看，PFHH 可能是由交感神经系统（腺体水平或神经末梢）的外周受累引起的，因为研究组之间没有差异。更具体的研究应该有助于阐明这个问题。