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Europium-Catalyzed Intramolecular Addition of Carboxylic Acid to Nonactivated Alkenes: An Efficient Route to Aryl-Substituted γ-Butyrolactone
Synlett ( IF 2 ) Pub Date : 2020-06-16 , DOI: 10.1055/s-0040-1707820
Mrinal K. Bera , Manas Bandyopadhyay , Abhijit Nayak

Europium(III)triflate has been proved to be an effective catalyst for intramolecular cyclization of aryl-substituted carboxylic acid to afford arylated γ-butyrolactone. Various attractive features, such as broad substrate scope, a wide range of functional group tolerance, operational simplicity, complete atom economy, and good-to-excellent yields have made this new protocol more appealing. Moreover, this method provides a practical alternative to the existing catalysts.

中文翻译:

铕催化的羧酸与未活化烯烃的分子内加成:制备芳基取代的 γ-丁内酯的有效途径

三氟甲磺酸铕 (III) 已被证明是芳基取代羧酸分子内环化生成芳基化 γ-丁内酯的有效催化剂。各种吸引人的特点,如广泛的底物范围、广泛的官能团耐受性、操作简单、完整的原子经济性和良好的产量,使这个新协议更具吸引力。此外,该方法为现有催化剂提供了实用的替代方案。
更新日期:2020-06-16
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