Poly(methyl methacrylate) (PMMA) bone cement is used as a minor void filler in revision total knee arthroplasty (rTKA). The application of PMMA is indicated only for peripheral bone defects with less than 5 mm depth and that cover less than 50% of the bone surface. Treating bone defects with PMMA results in complications as a result of volumetric shrinkage, bone necrosis, and aseptic loosening. These concerns have driven the development of alternative bone cements. We report here on novel modified glass polyalkenoate cements (mGPCs) containing 1, 5 and 15 wt% calcium sulfate (CaSO₄) and how the modified cements' properties compare to those of PMMA used in rTKA. CaSO₄ is incorporated into the mGPC to improve both osteoconductivity and bioresorbability. The results confirm that the incorporation of CaSO₄ into mGPCs decreases the setting time and increases release of therapeutic ions such as Ca²⁺ and Zn²⁺ over 30 days of maturation in deionized (DI) water. Moreover, the compressive strength for 5 and 15 wt% CaSO₄ addition increased to over 30 MPa after 30 day maturation. Although the overall initial compressive strength of the mGPC (~ 30 MPa) is less than PMMA (~ 95 MPa), the compressive strength of mGPC is closer to that of cancellous bone (~ 1.2–7.8 MPa). CaSO₄ addition did not affect biaxial flexural strength. Fourier transform infrared analysis indicated no cross‐linking between CaSO₄ and the GPC after 30 days. in vivo tests are required to determine the effects the modified GPCs as alternative on PMMA in rTKA.

中文翻译：

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用于翻修全膝关节置换术固定的含硫酸钙玻璃聚链烯酸水泥。

聚甲基丙烯酸甲酯 (PMMA) 骨水泥用作翻修全膝关节置换术 (rTKA) 中的微小空隙填充剂。PMMA 的应用仅适用于深度小于 5 毫米且覆盖骨表面小于 50% 的周边骨缺损。由于体积收缩、骨坏死和无菌性松动，用 PMMA 治疗骨缺损会导致并发症。这些担忧推动了替代骨水泥的开发。我们在此报告了含有 1、5 和 15 wt% 硫酸钙 (CaSO ₄ ) 的新型改性玻璃聚烯酸酯水泥 (mGPC)，以及改性水泥的性能与 rTKA 中使用的 PMMA 的性能相比如何。硫酸钙₄被纳入 mGPC 以改善骨传导性和生物可吸收性。结果证实，在去离子 (DI) 水中成熟 30 天后，将 CaSO ₄掺入 mGPC 可缩短凝固时间并增加治疗性离子（例如 Ca ²⁺和 Zn ^{2+ ）的}释放。此外，在成熟 30 天后，添加5 和 15 重量％的 CaSO _{4 的}抗压强度增加到超过 30 MPa。尽管 mGPC 的整体初始抗压强度 (~ 30 MPa) 小于 PMMA (~ 95 MPa)，但 mGPC 的抗压强度更接近于松质骨 (~ 1.2-7.8 MPa)。硫酸钙₄添加不影响双轴弯曲强度。傅里叶变换红外分析表明30 天后CaSO ₄和 GPC之间没有交联。需要体内试验来确定修饰的 GPC 作为替代物对 rTKA 中 PMMA 的影响。