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The UK Veterinary Immunological Toolbox Website: promoting vaccine research by facilitating communication and removing reagent barriers.
Immunology ( IF 6.4 ) Pub Date : 2020-06-16 , DOI: 10.1111/imm.13227
William Mwangi 1 , Giuseppe Maccari 1, 2 , Jayne C Hope 3 , Gary Entrican 3 , John A Hammond 1
Affiliation  

Using the best animal models to study immune responses against specific pathogens or vaccines can dramatically accelerate our understanding. Veterinary species are well studied, particularly livestock, to reduce their disease burden. They have also proven to be powerful models, especially for zoonotic pathogens and novel vaccination strategies. A prerequisite for any model selection is having the right quality and range of species‐specific immunological reagents. To help promote the widest possible use of veterinary species, an open access website (https://www.immunologicaltoolbox.co.uk) has been created as a central community annotated hub for veterinary immunological reagents. The website is also the portal into services offered by the UK Immunological Toolbox project that includes antibody generation, sequencing and recombinant expression. The funding for this effort is linked into sustainable sources, but ultimate success relies on community engagement to continually increase the quality and quantity of information. It is hoped that as more users and reagent owners engage, it will become an essential resource for researchers, veterinarians and clinicians alike by removing barriers that prevent the use of the most informative animal models.

中文翻译:

英国兽医免疫工具箱网站:通过促进交流和消除试剂障碍来促进疫苗研究。

使用最好的动物模型研究针对特定病原体或疫苗的免疫反应可以极大地促进我们的理解。对兽医物种,特别是牲畜,进行了充分的研究以减轻其疾病负担。它们也被证明是强大的模型,尤其是对于人畜共患病原体和新颖的疫苗接种策略。选择任何模型的先决条件是拥有正确质量和范围的物种特异性免疫试剂。为了帮助促进尽可能广泛地使用兽用物种,已经创建了一个开放式访问网站(https://www.immunologicaltoolbox.co.uk),作为带中央注解的兽用免疫试剂中心。该网站也是UK Immunological Toolbox项目提供的服务门户,包括抗体生成,测序和重组表达。这项工作的资金与可持续资源挂钩,但最终的成功取决于社区的参与,以不断提高信息的质量和数量。希望随着更多用户和试剂所有者的参与,它将成为消除研究人员阻碍使用最丰富信息的动物模型的障碍,从而成为研究人员,兽医和临床医生等必不可少的资源。
更新日期:2020-06-16
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