Metal–organic frameworks (MOFs) have applications in numerous fields. However, the development of MOF‐based “theranostic” macroscale devices is not achieved. Here, heparin‐coated biocompatible MOF/poly(ε‐caprolactone) (PCL) “theranostic” stents are developed, where NH₂‐Materials of Institute Lavoisier (MIL)‐101(Fe) encapsulates and releases rapamycin (an immunosuppressive drug). These stents also act as a remarkable source of contrast in ex vivo magnetic resonance imaging (MRI) compared to the invisible polymeric stent. The in vitro release patterns of heparin and rapamycin respectively can ensure a type of programmed model to prevent blood coagulation immediately after stent placement in the artery and stenosis over a longer term. Due to the presence of hydrolysable functionalities in MOFs, the stents are shown to be highly biodegradable in degradation tests under various conditions. Furthermore, there is no compromise of mechanical strength or flexibility with MOF compositing. The system described here promises many biomedical applications in macroscale theranostic devices. The use of MOF@PCL can render a medical device MRI‐visible while simultaneously acting as a carrier for therapeutic agents.

中文翻译：

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由金属有机框架增强的可生物降解 MRI 可见药物洗脱支架。

金属有机框架（MOF）在许多领域都有应用。然而，基于 MOF 的“治疗诊断”宏观设备的开发并未实现。在这里，开发了肝素涂层的生物相容性 MOF/聚（ε-己内酯）（PCL）“治疗诊断”支架，其中 NH ₂- 拉瓦锡研究所 (MIL)-101(Fe) 的材料封装并释放雷帕霉素（一种免疫抑制药物）。与不可见的聚合物支架相比，这些支架在离体磁共振成像 (MRI) 中也可作为显着的对比度来源。肝素和雷帕霉素的体外释放模式分别可以确保一种程序模型，以防止动脉支架置入后立即发生血液凝固和长期狭窄。由于 MOF 中存在可水解的官能团，支架在各种条件下的降解测试中显示出高度可生物降解的特性。此外，MOF 复合材料不会影响机械强度或柔韧性。这里描述的系统承诺在宏观治疗设备中的许多生物医学应用。