Bioactive metal–organic frameworks (bio‐MOFs) built from biofunctional metal ions and linkers show a new strategy to construct multifunctional theranostic platforms. Herein, a bio‐MOF is synthetized via the self‐assembling of Fe³⁺ ions and doxorubicin hydrochloride (DOX) molecules. Then, through a stepwise assembly strategy, another bio‐MOFs structure consisting of Gd³⁺ ions and 1,3,5‐benzenetricarboxylic acid (H₃BTC) is wrapped on the surfaces of Fe‐DOX nanoparticles, followed by adsorbing photosensitizer indocyanine green (ICG). Specifically, the Gd‐MOF shell structure can not only act as a contrast agent for magnetic resonance imaging (MRI), but also provides protection for Fe‐DOX cores, controlling the release of DOX. The photoacoustic and photothermal imaging (PAI and PTI) methods are successfully introduced to the platform by loading ICG, providing potential applications for multimodal biological imaging. The in vitro and in vivo outcomes indicate that the Fe‐DOX@Gd‐MOF‐ICG nanoplatform exhibits outstanding synergistic antitumor performance via MR/PA/PT imaging guided chemotherapy, photothermal and photodynamic combination therapy. The work may encourage further exploration of bio‐MOFs based multifunctional theranostic platforms for multimodal imaging guided compound antitumor therapy, which will open an avenue of MOFs toward biological applications.

中文翻译：

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基于生物活性MOF的治疗剂，可有效实现多模式成像与化学光疗的高效结合。

由生物功能金属离子和连接基构建的生物活性金属有机框架（bio-MOF）显示了构建多功能治疗学平台的新策略。本文中，通过MO ³⁺离子和阿霉素盐酸盐（DOX）分子的自组装合成了生物MOF 。然后，通过逐步组装策略，由Gd ³⁺离子和1,3,5-苯三羧酸（H ₃BTC）包裹在Fe-DOX纳米颗粒的表面上，然后吸附光敏剂吲哚菁绿（ICG）。特别是，Gd-MOF壳结构不仅可以充当磁共振成像（MRI）的造影剂，而且还可以保护Fe-DOX核，控制DOX的释放。通过加载ICG，成功将光声和光热成像（PAI和PTI）方法引入平台，为多模式生物成像提供了潜在的应用。体外和体内结果表明，Fe-DOX @ Gd-MOF-ICG纳米平台通过MR / PA / PT成像引导的化学疗法，光热和光动力联合疗法表现出出色的协同抗肿瘤性能。