A ball-milling enabled chemoselective activation of amides via N-tert-butoxycarbonylation catalyzed by 4-dimethylaminopyridine is described under solvent-free conditions. High chemoselectivity with respect to NH acidity of amides has been observed. A one-pot two-step procedure for selective esterification of amides has been demonstrated in model reaction of benzamides with p-cresol and benzyl alcohol.

中文翻译：

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球磨可实现高度选择性的无溶剂N-叔丁氧羰基化反应，以活化酰胺

甲球磨经由启用酰胺的化学选择性激活ñ -叔-butoxycarbonylation催化由4-二甲氨基吡啶是无溶剂的条件下进行说明。已经观察到相对于酰胺的NH酸度具有高化学选择性。在苯甲酰胺与对甲酚和苯甲醇的模型反应中，已经证明了一锅两步的酰胺选择性酯化方法。