Research question

Are there differences in the cardiometabolic health of ICSI-conceived adolescents compared with a control group, taking parental risk factors into account?

Design

ICSI-conceived adolescents (n = 272), their mothers (n = 273) and naturally conceived control adolescents (n = 273) and their mothers (n = 273) provided a blood test and answered a health-related questionnaire. The adolescents also attended a physical examination.

Results

ICSI-conceived males showed significantly higher mean weight (72.6 ± 15.1 versus 67.7 ± 12.6 kg, P = 0.005), body mass index (BMI) (22.2 ± 3.7 versus 21.0 ± 3.2 kg/m², P = 0.007) and waist circumference (79.1 ± 11.6 versus 74.5 ± 8.7 cm, P < 0.001). The mean values for weight and BMI were also significantly higher in the ICSI parents. In the ICSI-conceived females significant differences in high-density lipoprotein cholesterol (1.5 ± 0.3 versus 1.6 ± 0.3 mmol/l, P = 0.033) and triglyceride values (1.1 ± 0.5 versus 1.0 ± 0.4 mmol/l, P = 0.013) were observed. ICSI mothers also had significantly higher triglycerides (P = 0.002), higher glutamate pyruvate transaminase/alanine aminotransferase (P < 0.001) and higher alkaline phosphatase values (P < 0.001).

Conclusions

Increased values for weight were found in the male and differences in lipid parameters in the female ICSI-conceived adolescents, which were reflected in the values of their parents. Adjustment for parental risk factors generally attenuated the differences between the ICSI and the control groups, but did not completely remove them. Whether these observed differences are clinically relevant for the future health of the participants requires further study. To increase knowledge in this area, future studies should also include parental data.

中文翻译：

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ICSI 受孕和自然受孕青少年的代谢健康参数比较。

研究问题

考虑到父母的危险因素，ICSI 受孕青少年的心脏代谢健康与对照组相比是否存在差异？

设计

ICSI 受孕的青少年 ( n  = 272)、他们的母亲 ( n  = 273) 和自然受孕的对照青少年 ( n  = 273) 和他们的母亲 ( n  = 273) 提供了血液测试并回答了与健康相关的问卷。青少年还参加了体检。

结果

ICSI 受孕男性的平均体重（72.6 ± 15.1 与 67.7 ± 12.6 kg，P  = 0.005）、体重指数（BMI）（22.2 ± 3.7 与 21.0 ± 3.2 kg/m ²，P  = 0.007）和腰围显着更高（79.1 ± 11.6 与 74.5 ± 8.7 厘米，P  < 0.001）。ICSI 父母的体重和 BMI 平均值也显着更高。在 ICSI 受孕女性中，高密度脂蛋白胆固醇（1.5 ± 0.3 对 1.6 ± 0.3 mmol/l，P  = 0.033）和甘油三酯值（1.1 ± 0.5 对 1.0 ± 0.4 mmol/l，P  = 0.013）的显着差异为观察到的。ICSI 母亲的甘油三酯也显着升高（P = 0.002)、更高的谷氨酸丙酮酸转氨酶/丙氨酸转氨酶 ( P  < 0.001) 和更高的碱性磷酸酶值 ( P  < 0.001)。

结论

男性体重增加，女性 ICSI 受孕青少年的血脂参数存在差异，这反映在他们父母的数值上。对父母风险因素的调整通常会减弱 ICSI 和对照组之间的差异，但并没有完全消除它们。这些观察到的差异是否与参与者未来的健康在临床上相关需要进一步研究。为了增加这方面的知识，未来的研究还应该包括父母的数据。