Unlike age-related brain changes linked to motor activity, neural alterations related to self-motion perception remain unknown. Using fMRI data, we investigated age-related changes in the central processing of somatosensory information by inducing illusions of right-hand rotations with specific proprioceptive and tactile stimulation. Functional connectivity during resting-state (rs-FC) was also compared between younger and older participants. Results showed common sensorimotor activations in younger and older adults during proprioceptive and tactile illusions, but less deactivation in various right frontal regions and the precuneus were found in the elderly. Older participants exhibited a less-lateralized pattern of activity across the primary sensorimotor cortices (SM1) in the proprioceptive condition only. This alteration of the interhemispheric balance correlated with declining individual performance in illusion velocity perception from a proprioceptive, but not a tactile, origin. By combining task-related data, rs-FC and behavioral performance, this study provided consistent results showing that hand movement perception was altered in the elderly, with a more pronounced deterioration of the proprioceptive system, likely due to the breakdown of inhibitory processes with aging. Nevertheless, older people could benefit from an increase in internetwork connectivity to overcome this kinesthetic decline.

中文翻译：

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老年人手部运动感知的功能性大脑变化：本体感觉的损伤比触觉更大

与与运动活动相关的与年龄相关的大脑变化不同，与自我运动感知相关的神经变化仍然未知。使用 fMRI 数据，我们通过特定的本体感觉和触觉刺激诱发右手旋转的错觉，研究了体感信息中央处理中与年龄相关的变化。还比较了年轻和年长参与者在静息状态 (rs-FC) 期间的功能连接。结果显示，在本体感觉和触觉错觉期间，年轻人和老年人常见的感觉运动激活，但在老年人中发现的各个右额叶区域和楔前叶的失活较少。仅在本体感觉条件下，年长的参与者在初级感觉运动皮层 (SM1) 上表现出较少的侧向活动模式。这种半球间平衡的改变与个体在来自本体感觉而非触觉起源的幻觉速度感知中的表现下降相关。通过结合与任务相关的数据、rs-FC 和行为表现，这项研究提供了一致的结果，表明老年人的手部运动感知发生了改变，本体感觉系统的恶化更为明显，这可能是由于随着年龄的增长抑制过程的破坏. 尽管如此，老年人可以从互联网连接的增加中受益，以克服这种动觉下降。这项研究提供了一致的结果，表明老年人的手部运动感知发生了改变，本体感觉系统的恶化更为明显，这可能是由于随着年龄的增长抑制过程的破坏。尽管如此，老年人可以从互联网连接的增加中受益，以克服这种动觉下降。这项研究提供了一致的结果，表明老年人的手部运动感知发生了改变，本体感觉系统的恶化更为明显，这可能是由于随着年龄的增长抑制过程的破坏。尽管如此，老年人可以从互联网连接的增加中受益，以克服这种动觉下降。