Research into the pathophysiology of psoriasis remains challenging, because this disease does not occur naturally in laboratory animals. However, specific aspects of its complex immune-pathology can be illuminated through transgenic, knockout, xenotransplantation, immunological reconstitution, drug-induced, or spontaneous mutation models in rodents. Although some of these approaches have already been pursued for more than 5 decades and even more models have been described in recent times, they have surprisingly not yet been systematically validated. As a consequence, researchers regularly examine specific aspects that only partially reflect the complex overall picture of the human disease. Nonetheless, animal models are of great utility to investigate inflammatory mediators, the communication between cells of the innate and the adaptive immune systems, the role of resident cells as well as new therapies. Of note, various manipulations in experimental animals resulted in rather similar phenotypes. These were called “psoriasiform”, “psoriasis-like” or even “psoriasis” usually on the basis of some similarities with the human disorder. Xenotransplantation of human skin onto immunocompromised animals can overcome this limitation only in part. In this review, we elucidate approaches for the generation of animal models of psoriasis and assess their strengths and limitations with a certain focus on more recently developed models.

银屑病的病理生理学研究仍然具有挑战性，因为这种疾病不会在实验室动物中自然发生。然而，其复杂免疫病理学的特定方面可以通过啮齿动物的转基因、敲除、异种移植、免疫重建、药物诱导或自发突变模型来阐明。尽管其中一些方法已经被采用了 5 年以上，并且最近已经描述了更多模型，但令人惊讶的是，它们尚未得到系统验证。因此，研究人员会定期检查仅部分反映人类疾病复杂整体情况的特定方面。尽管如此，动物模型对于研究炎症介质非常有用，先天细胞和适应性免疫系统之间的交流、常驻细胞的作用以及新疗法。值得注意的是，对实验动物的各种操作导致了相当相似的表型。这些被称为“银屑病样”、“银屑病样”甚至“银屑病”，通常是基于与人类疾病的一些相似之处。将人类皮肤异种移植到免疫功能低下的动物身上只能部分克服这一限制。在这篇综述中，我们阐明了生成银屑病动物模型的方法，并评估了它们的优势和局限性，重点关注最近开发的模型。“银屑病样”甚至“银屑病”通常基于与人类疾病的一些相似之处。将人类皮肤异种移植到免疫功能低下的动物身上只能部分克服这一限制。在这篇综述中，我们阐明了生成银屑病动物模型的方法，并评估了它们的优势和局限性，重点关注最近开发的模型。“银屑病样”甚至“银屑病”通常基于与人类疾病的一些相似之处。将人类皮肤异种移植到免疫功能低下的动物身上只能部分克服这一限制。在这篇综述中，我们阐明了生成银屑病动物模型的方法，并评估了它们的优势和局限性，重点关注最近开发的模型。