Recent analysis concerning the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)- angiotensin converting enzyme (ACE) receptor interaction in enterocytes, the definition of gut-lung axis, as well as the molecular basis of sialic acid-related dual recognition concept in gastrointestinal SARS-CoV-2 infection, have brought a new perspective to potential therapeutic targets. In this review evolving research and clinical data on gastrointestinal SARS-CoV-2 infection are discussed in the context of viral fusion and entry mechanisms, focusing on the different triggers used by coronaviruses. Furthermore, it is emphasized that the viral spike protein is prevented from binding gangliosides, which are composed of a glycosphingolipid with one or more sialic acids, in the presence of chloroquine or hydroxychloroquine. In gastrointestinal SARS-CoV-2 infection the efficiency of these repositioned drugs is debated.

严重急性呼吸系统综合症冠状病毒2（SARS-CoV-2）-肠细胞血管紧张素转换酶（ACE）受体相互作用的最新分析、肠肺轴的定义以及唾液酸相关双重识别的分子基础胃肠道 SARS-CoV-2 感染的概念，为潜在的治疗靶点带来了新的视角。在这篇综述中，在病毒融合和进入机制的背景下讨论了关于胃肠道 SARS-CoV-2 感染的不断发展的研究和临床数据，重点是冠状病毒使用的不同触发因素。此外，需要强调的是，在氯喹或羟氯喹存在的情况下，病毒刺突蛋白无法与神经节苷脂结合，神经节苷脂由鞘糖脂和一种或多种唾液酸组成。