Macrophages are key players in wound healing- along with mediating the acute inflammatory response, macrophages activate cutaneous epithelial cells and promote tissue repair. Diabetes complications, including diabetic chronic wounds, are accompanied by persistent inflammation and macrophage malfunction. Several studies indicate that hyperglycemia induces various alterations that affect macrophage function in wound healing including epigenetic changes, imbalance between pro- and anti-inflammatory modulators, and insensitivity to proliferative stimuli. In this review, we briefly summarize recent studies regarding those alterations and their implications on skin well-being in diabetes.

巨噬细胞是伤口愈合的关键因素-除了介导急性炎症反应外，巨噬细胞还可以激活皮肤上皮细胞并促进组织修复。糖尿病并发症，包括糖尿病慢性伤口，伴有持续性炎症和巨噬细胞功能异常。数项研究表明，高血糖症会诱发影响伤口愈合中巨噬细胞功能的各种变化，包括表观遗传学变化，促炎和抗炎调节剂之间的不平衡以及对增殖刺激的不敏感性。在这篇综述中，我们简要总结了有关这些改变及其对糖尿病皮肤健康的影响的最新研究。