当前位置:
X-MOL 学术
›
Brain Behav. Immun.
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Psychosocial factors and hospitalisations for COVID-19: Prospective cohort study based on a community sample
Brain, Behavior, and Immunity ( IF 15.1 ) Pub Date : 2020-10-01 , DOI: 10.1016/j.bbi.2020.06.021 G D Batty 1 , I J Deary 2 , M Luciano 3 , D M Altschul 3 , M Kivimäki 1 , C R Gale 4
Brain, Behavior, and Immunity ( IF 15.1 ) Pub Date : 2020-10-01 , DOI: 10.1016/j.bbi.2020.06.021 G D Batty 1 , I J Deary 2 , M Luciano 3 , D M Altschul 3 , M Kivimäki 1 , C R Gale 4
Affiliation
Abstract Background While certain infectious diseases have been linked to socioeconomic disadvantage, mental health problems, and lower cognitive function, relationships with COVID-19 are either uncertain or untested. Our objective was to examine the association of a range of psychosocial factors with hospitalisation for COVID-19. Methods UK Biobank, a prospective cohort study, comprises around half a million people who were aged 40 to 69 years at study induction between 2006 and 2010 when information on psychosocial factors and covariates were captured. Hospitalisation for COVID-19 were ascertained between 16th March and 26th April 2020. Results There were 908 hospitalisations for COVID-19 in an analytical sample of 431,051 England-based study members. In age- and sex-adjusted analyses, an elevated risk of COVID-19 was related to disadvantaged levels of education (odds ratio; 95% confidence interval: 2.05; 1.70, 2.47), income (2.00; 1.63, 2,47), area deprivation (2.20; 1.86, 2.59), occupation (1.39; 1.14, 1.69), psychological distress (1.58; 1.32, 1.89), mental health (1.50; 1.25, 1.79), neuroticism (1.19; 1.00, 1.42), and performance on two tests of cognitive function – verbal and numerical reasoning (2.66; 2.06, 3.34) and reaction speed (1.27; 1.08, 1.51). These associations were graded (p-value for trend ≤0.038) such that effects were apparent across the full psychosocial continua. After mutual adjustment for these characteristics plus ethnicity, comorbidity, and lifestyle factors, only the relationship between lower cognitive function as measured using the reasoning test and a doubling in the risk of the infection remained (1.98; 1.38, 2.85). Conclusions A range of psychosocial factors revealed associations with hospitalisations for COVID-19 of which the relation with cognitive function, a marker of health literacy, was most robust.
中文翻译:
COVID-19 的心理社会因素和住院治疗:基于社区样本的前瞻性队列研究
摘要 背景 虽然某些传染病与社会经济劣势、心理健康问题和认知功能较低有关,但与 COVID-19 的关系要么不确定,要么未经检验。我们的目标是检查一系列心理社会因素与 COVID-19 住院治疗的关联。方法 UK Biobank 是一项前瞻性队列研究,在 2006 年至 2010 年研究启动时收集了大约 50 万名年龄在 40 至 69 岁之间的人,当时收集了有关心理社会因素和协变量的信息。2020 年 3 月 16 日至 4 月 26 日期间确定了 COVID-19 住院情况。结果 在 431,051 名英格兰研究成员的分析样本中,有 908 人因 COVID-19 住院。在年龄和性别调整分析中,COVID-19 风险升高与弱势教育水平(优势比;95% 置信区间:2.05;1.70,2.47)、收入(2.00;1.63,2,47)、区域剥夺(2.20; 1.86, 2.59)、职业(1.39; 1.14, 1.69)、心理困扰(1.58; 1.32, 1.89)、心理健康(1.50; 1.25, 1.79)、神经质(1.19; 1.00, 1.42)和表现两项认知功能测试——语言和数字推理(2.66;2.06,3.34)和反应速度(1.27;1.08,1.51)。这些关联被分级(趋势 p 值≤0.038),以便在整个心理社会连续体中产生明显的影响。在对这些特征加上种族、合并症和生活方式因素进行相互调整后,只有使用推理测试测量的较低认知功能与感染风险加倍之间的关系仍然存在(1.98;1.38,2.85)。结论 一系列心理社会因素揭示了与 COVID-19 住院治疗的相关性,其中与认知功能(健康素养的标志)的关系最为密切。
更新日期:2020-10-01
中文翻译:
COVID-19 的心理社会因素和住院治疗:基于社区样本的前瞻性队列研究
摘要 背景 虽然某些传染病与社会经济劣势、心理健康问题和认知功能较低有关,但与 COVID-19 的关系要么不确定,要么未经检验。我们的目标是检查一系列心理社会因素与 COVID-19 住院治疗的关联。方法 UK Biobank 是一项前瞻性队列研究,在 2006 年至 2010 年研究启动时收集了大约 50 万名年龄在 40 至 69 岁之间的人,当时收集了有关心理社会因素和协变量的信息。2020 年 3 月 16 日至 4 月 26 日期间确定了 COVID-19 住院情况。结果 在 431,051 名英格兰研究成员的分析样本中,有 908 人因 COVID-19 住院。在年龄和性别调整分析中,COVID-19 风险升高与弱势教育水平(优势比;95% 置信区间:2.05;1.70,2.47)、收入(2.00;1.63,2,47)、区域剥夺(2.20; 1.86, 2.59)、职业(1.39; 1.14, 1.69)、心理困扰(1.58; 1.32, 1.89)、心理健康(1.50; 1.25, 1.79)、神经质(1.19; 1.00, 1.42)和表现两项认知功能测试——语言和数字推理(2.66;2.06,3.34)和反应速度(1.27;1.08,1.51)。这些关联被分级(趋势 p 值≤0.038),以便在整个心理社会连续体中产生明显的影响。在对这些特征加上种族、合并症和生活方式因素进行相互调整后,只有使用推理测试测量的较低认知功能与感染风险加倍之间的关系仍然存在(1.98;1.38,2.85)。结论 一系列心理社会因素揭示了与 COVID-19 住院治疗的相关性,其中与认知功能(健康素养的标志)的关系最为密切。