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Comparative Analysis of the Structure of Three piRNA Clusters in the Drosophila melanogaster Genome
Molecular Biology ( IF 1.2 ) Pub Date : 2020-06-17 , DOI: 10.1134/s0026893320030085
A. P. Kotnova , Yu. V. Ilyin

Abstract

Here we attempt to reconstruct the sequence of events that led to the formation of three regulatory piRNA clusters, namely, 20A, 38C and flamenco in the Drosophila melanogaster genome. Both the 38C and flamenco clusters include inverted sequences, which potentially form double-stranded RNA hairpins. We present evidence in favor of the well-known hypothesis of piRNA clusters as “transposon traps”. According to this model, the presence of the only copy of the transposon in the genome indicates that its expression is suppressed by an RNA-interference mechanism immediately after the mobile element enters the piRNA cluster. We also discuss high the structural variability of piRNAs in Drosophila clusters and cases of horizontal transmobile elements between related species.


中文翻译:

果蝇基因组中三个piRNA簇的结构的比较分析。

摘要

在这里,我们试图重建的事件导致的三方监管piRNA基因簇,即20A,38C和形成的序列弗拉门戈果蝇基因组中。38C和弗拉门戈簇均包含反向序列,这些序列可能形成双链RNA发夹。我们提供证据支持piRNA簇作为“转座子陷阱”的众所周知的假设。根据该模型,转座子在基因组中只有一个拷贝的存在表明其表达在移动元件进入piRNA簇后立即被RNA干扰机制抑制。我们还讨论了果蝇中piRNA的高结构变异性 相关物种之间水平可移动元素的簇和案例。
更新日期:2020-06-17
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