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Prospective Applications of Single-Domain Antibodies in Biomedicine
Molecular Biology ( IF 1.2 ) Pub Date : 2020-06-17 , DOI: 10.1134/s0026893320030164
S. V. Tillib

Abstract

Methods that utilize highly specific antibodies, anti-idiotypic antibodies, various recombinant molecules with antibody properties and immunocorrection and immunoprophylaxis with the help of vaccines are in demand and are intensely developed in the field of biomedicine. Techniques to generate specific single-domain recombinant antibodies (nanobodies) and their derivatives have raised great expectations in the past years. The review considers the recent literature data on the use of nanobodies in basic research, diagnosis, and design of new immunotherapeutic agents. Special sections focus on the prospects of using nanobodies as targeted molecules of microbiota components, the use of anti-idiotypic nanobodies, and a search for promising targets for early diagnosis based on nanobodies.


中文翻译:

单域抗体在生物医学中的前瞻性应用

摘要

利用高特异性抗体,抗独特型抗体,具有抗体特性的各种重组分子以及借助于疫苗的免疫校正和免疫预防的方法是需要的,并且在生物医学领域中得到了大力发展。在过去的几年中,产生特异性单结构域重组抗体(纳米抗体)及其衍生物的技术引起了人们极大的期望。该综述考虑了有关纳米抗体在基础研究,诊断和新免疫治疗剂设计中的使用的最新文献数据。特别的部分集中于使用纳米抗体作为微生物群组分的靶向分子的前景,抗独特型纳米抗体的使用以及基于纳米抗体的早期诊断的有希望的目标的寻找。
更新日期:2020-06-17
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