Infants born small for gestational age (SGA) are known to have increased risk of developing several pathologies, including the metabolic syndrome, when they grow up. It has been described that both the growth pattern of these children as well as the risk of their presenting future metabolic disorders can be influenced by the expression of adipokines. Among them, chemerin has demonstrated to be implicated in lipid and glucose metabolism, presenting higher circulating concentration in diabetic and obese subjects. Thus, the aim of this study was to analyze the association of anthropometric parameters and plasmatic biochemical parameters with circulating chemerin concentration in SGA children. This prospective, longitudinal study was carried out in plasma samples of Caucasian children born SGA at Hospital Universitario de Álava-Txagorritxu. Significant positive correlations were observed between chemerin concentrations at 3 months and insulin values at 3 months and also with triglyceride levels at 24 months. These associations were maintained after adjustment by anthropometric parameters. Therefore, we suggest that circulating chemerin concentration, measured at an early age, might be an indicator of future metabolic alterations in SGA children.

众所周知，出生时小于胎龄 (SGA) 的婴儿长大后患多种疾病的风险会增加，包括代谢综合征。据描述，这些儿童的生长模式以及他们未来出现代谢紊乱的风险都可能受到脂肪因子表达的影响。其中，chemerin 已被证明与脂质和葡萄糖代谢有关，在糖尿病和肥胖受试者中表现出更高的循环浓度。因此，本研究的目的是分析人体测量参数和血浆生化参数与 SGA 儿童循环凯莫瑞浓度的关联。这项前瞻性纵向研究是在医院 Universitario de Álava-Txagorritxu 对出生 SGA 的白人儿童的血浆样本进行的。在 3 个月时的凯莫瑞浓度与 3 个月时的胰岛素值以及与 24 个月时的甘油三酯水平之间观察到显着的正相关。这些关联在通过人体测量参数调整后得以维持。因此，我们建议在早期测量的循环凯莫瑞浓度可能是 SGA 儿童未来代谢改变的指标。