当前位置: X-MOL 学术Appl. Nanosci. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Synthesis of nanostructured mesoporous silica-coated magnetic nuclei with polyelectrolyte layers for tetracycline hydrochloride control release
Applied Nanoscience ( IF 3.869 ) Pub Date : 2020-06-15 , DOI: 10.1007/s13204-020-01482-z
Alex Carvalho Alavarse , Carlos Eduardo de Castro , Luana dos Santos Andrade , Fabio Furlan Ferreira , Jean Jacques Bonvent

Colloidal drug delivery systems are one of the most promising tools for the treatment of several diseases. We present a synthesis route based on four steps involving mesoporous silica-coated magnetite nanoparticles (MNPs) capped by polyelectrolyte (PE) assembling. The morphology and physical properties of the different components of the system were investigated. The magnetite phase of the iron oxide nanoparticles was identified by X-ray diffraction before their incorporation into the mesoporous silica matrix by a sol–gel process. A MCM-41-like organized hexagonal mesoporous (≈4.2 nm) structure was achieved, as ensured by the αS-plot model. Polyethylenimine PEI and sodium alginate (ALG) PE layer-by-layer capping were successfully performed by simple successive dispersions of nanoparticles in the PE solution bath. TEM images confirmed a well-organized structure, as also supported by DLS and XPS analyses, which present an increase in diameter size and distinct chemical surface composition after each step of the synthesis. The two successive coatings of the MNPs induced a significative decrease of the magnetic susceptibility but kept sufficient intensity for drug delivery assisted by an external magnetic field. To validate the system as drug delivery, in vitro tetracycline hydrochloride (TCH) loading and release studies were performed in PBS solution for 48 h. It was found that the TCH-loaded uncapped mesoporous silica NPs released more than 90% of TCH after 48 h. Meanwhile, when capped by the PEs, only 30% of the total drug amount was released, due to a hindrance of the drug diffusion by the PE layer. The present work suggests that the combination of the low cost and non-toxic hybrid system proposed has potential use in nanomedicine as a drug delivery vehicle.



中文翻译:

具有聚电解质层的纳米结构介孔二氧化硅包覆的磁核的合成用于盐酸四环素的控制释放

胶体药物递送系统是用于治疗多种疾病的最有前途的工具之一。我们提出了基于四个步骤的合成路线,涉及由介孔二氧化硅涂层的磁铁矿纳米颗粒(MNPs)覆盖的聚电解质(PE)组装。研究了系统不同组件的形态和物理特性。通过X射线衍射鉴定出氧化铁纳米颗粒的磁铁矿相,然后通过溶胶-凝胶法将其掺入介孔二氧化硅基质中。甲MCM-41样组织六方介孔(≈4.2纳米)结构实现的,由α为确保小号图模型。聚乙烯亚胺PEI和海藻酸钠(ALG)PE逐层覆盖是通过将纳米颗粒简单连续分散在PE溶液浴中而成功完成的。TEM图像证实了组织良好的结构,这也得到DLS和XPS分析的支持,在合成的每个步骤之后,直径大小都会增加,并且化学表面组成也有所不同。MNP的两个连续涂层引起磁化率显着降低,但在外部磁场的辅助下仍保持足够的强度以用于药物输送。为了验证该系统是否为药物递送系统,在PBS溶液中进行了盐酸四环素(TCH)体外加载和释放研究48小时。发现在48小时后,装载TCH的未封端中孔二氧化硅NPs释放了TCH的90%以上。与此同时,当被PE覆盖时,由于PE层阻碍了药物扩散,因此仅释放了总量的30%。目前的工作表明,所提出的低成本和无毒的混合系统的组合在纳米医学中作为药物输送载体具有潜在的用途。

更新日期:2020-06-15
down
wechat
bug