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Macrophage-cancer hybrid membrane-coated nanoparticles for targeting lung metastasis in breast cancer therapy.
Journal of Nanobiotechnology ( IF 10.2 ) Pub Date : 2020-06-16 , DOI: 10.1186/s12951-020-00649-8
Chunai Gong 1 , Xiaoyan Yu 1 , Benming You 2 , Yan Wu 1 , Rong Wang 1 , Lu Han 1 , Yujie Wang 1 , Shen Gao 2 , Yongfang Yuan 1
Affiliation  

Cell membrane- covered drug-delivery nanoplatforms have been garnering attention because of their enhanced bio-interfacing capabilities that originate from source cells. In this top-down technique, nanoparticles (NPs) are covered by various membrane coatings, including membranes from specialized cells or hybrid membranes that combine the capacities of different types of cell membranes. Here, hybrid membrane-coated doxorubicin (Dox)-loaded poly(lactic-co-glycolic acid) (PLGA) NPs (DPLGA@[RAW-4T1] NPs) were fabricated by fusing membrane components derived from RAW264.7(RAW) and 4T1 cells (4T1). These NPs were used to treat lung metastases originating from breast cancer. This study indicates that the coupling of NPs with a hybrid membrane derived from macrophage and cancer cells has several advantages, such as the tendency to accumulate at sites of inflammation, ability to target specific metastasis, homogenous tumor targeting abilities in vitro, and markedly enhanced multi-target capability in a lung metastasis model in vivo. The DPLGA@[RAW-4T1] NPs exhibited excellent chemotherapeutic potential with approximately 88.9% anti-metastasis efficacy following treatment of breast cancer-derived lung metastases. These NPs were robust and displayed the multi-targeting abilities of hybrid membranes. This study provides a promising biomimetic nanoplatform for effective treatment of breast cancer metastasis.

中文翻译:

用于乳腺癌治疗中靶向肺转移的巨噬细胞-癌症杂化膜涂层纳米颗粒。

细胞膜覆盖的药物递送纳米平台因其源于源细胞的增强的生物界面功能而备受关注。在这种自上而下的技术中,纳米颗粒(NPs)被各种膜涂层覆盖,包括来自特殊细胞的膜或混合了不同类型细胞膜容量的混合膜。在这里,通过融合衍生自RAW264.7(RAW)的膜组分和混合的膜包被的阿霉素(Dox)负载的聚乳酸-乙醇酸共聚物(PLGA)NP(DPLGA @ [RAW-4T1] NPs)制成。 4T1单元格(4T1)。这些NP被用于治疗源自乳腺癌的肺转移。这项研究表明,NP与巨噬细胞和癌细胞衍生的杂交膜的偶联具有许多优势,例如在炎症部位积聚的趋势,靶向特定转移的能力,体外的均质肿瘤靶向能力以及体内肺转移模型中的多靶点能力显着增强。DPLGA @ [RAW-4T1] NPs在治疗乳腺癌衍生的肺转移后,具有出色的化学治疗潜力,具有约88.9%的抗转移功效。这些NP具有鲁棒性,并显示了杂化膜的多目标能力。这项研究为有效治疗乳腺癌转移提供了一种有前途的仿生纳米平台。DPLGA @ [RAW-4T1] NPs在治疗乳腺癌衍生的肺转移后,具有出色的化学治疗潜力,具有约88.9%的抗转移功效。这些NP具有鲁棒性,并显示了杂化膜的多目标能力。这项研究为有效治疗乳腺癌转移提供了一种有前途的仿生纳米平台。DPLGA @ [RAW-4T1] NPs在治疗乳腺癌衍生的肺转移后,具有出色的化学治疗潜力,具有约88.9%的抗转移功效。这些NP具有鲁棒性,并显示了杂化膜的多目标能力。这项研究为有效治疗乳腺癌转移提供了一种有前途的仿生纳米平台。
更新日期:2020-06-16
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