Abstract

A perspective on the literature dealing with the organocatalytic asymmetric preparation of axially chiral N-heterocycles is provided. A particular focus is devoted to rationalize the synthetic strategies employed in each case. Moreover, specific classes of organocatalysts are shown to stand out as privileged motives for the stereoselective preparation of such synthetically challenging molecular architectures. Finally, an overview of the main trends in the field is given.

1 Introduction

2 Five-Membered Rings

2.1 Arylation

2.2 Dynamic Kinetic Resolution

2.3 Ring Construction

2.4 Central-to-Axial Chirality Conversion and Chirality Transfer

2.5 Desymmetrization

3 Six-Membered Rings

3.1 Desymmetrization

3.2 (Dynamic) Kinetic Resolution

3.3 Ring Construction

3.4 Central-to-Axial Chirality Conversion

4 Conclusion

中文翻译：

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阻转异构N-杂环的有机催化不对称方法。

摘要

提供了有关轴向手性N-杂环的有机催化不对称制备的文献的观点。专门致力于合理化每种情况下使用的综合策略。而且，显示出特定种类的有机催化剂是立体选择性地制备这种具有合成挑战性的分子结构的优先动机。最后，概述了该领域的主要趋势。

1引言

2五面环

2.1丙烯酸化

2.2动态动力学分辨率

2.3环的构造

2.4中心到轴向手性转换和手性传递

2.5去对称

3个六元戒指

3.1去对称化

3.2（动态）动力学分辨率

3.3环的构造

3.4中轴手性转换

4。结论