Scaling, a phenomenon showing an abnormal detachment of the stratum corneum (SC) owing to desquamation dysfunction, is commonly observed in various skin diseases or xerotic skin due to ageing and low humidity. Therefore, it is considered that ameliorating the disturbed desquamatory process of the SC leads to improvement in scaling. Carbon dioxide (CO₂) is known to be good for some skin diseases; however, the effect of CO₂ on scaling and its mechanism are not sufficiently clear. We aimed to elucidate the effect of transepidermal application of CO₂ on scaling and its mechanism of action.

中文翻译：

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二氧化碳通过蛋白酶活化改善干燥鳞状皮肤的脱屑。

脱屑是由于脱屑功能障碍导致角质层（SC）异常脱离的现象，常见于各种皮肤病或由于老化和低湿度引起的干燥皮肤。因此，认为改善SC的受干扰的脱屑过程导致改善缩放。众所周知，二氧化碳 (CO ₂ ) 对某些皮肤病有益；然而，CO ₂对结垢的影响及其机理尚不十分清楚。我们旨在阐明 CO ₂经表皮应用对结垢的影响及其作用机制。