Sewall Wright developed F_ST for describing population differentiation and it has since been extended to many novel applications, including the detection of homomorphic sex chromosomes. However, there has been confusion regarding the expected estimate of F_ST for a fixed difference between the X‐ and Y‐chromosome when comparing males and females. Here, we attempt to resolve this confusion by contrasting two common F_ST estimators and explain why they yield different estimates when applied to the case of sex chromosomes. We show that this difference is true for many allele frequencies, but the situation characterized by fixed differences between the X‐ and Y‐chromosome is among the most extreme. To avoid additional confusion, we recommend that all authors using F_ST clearly state which estimator of F_ST their work uses.

中文翻译：

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FST 估计量的分歧：来自性染色体的案例研究。

Sewall Wright 开发了F _ST来描述种群分化，此后它已扩展到许多新应用，包括检测同态性染色体。然而，在比较男性和女性时，对于 X 和 Y 染色体之间固定差异的F _ST预期估计存在混淆。在这里，我们试图通过对比两个常见的F _ST来解决这种混淆估计量并解释为什么它们在应用于性染色体的情况下会产生不同的估计值。我们表明这种差异对于许多等位基因频率来说是真实的，但以 X 和 Y 染色体之间固定差异为特征的情况是最极端的。为避免进一步混淆，我们建议所有使用F _{ST 的}作者明确说明他们的工作使用的F _ST估计量。