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Age-dependent dose calculations for common PET radionuclides and brain radiotracers in nonhuman primate computational models.
Medical Physics ( IF 3.8 ) Pub Date : 2020-06-15 , DOI: 10.1002/mp.14333
Tianwu Xie 1, 2 , Xin Chen 1 , Habib Zaidi 2, 3, 4, 5
Affiliation  

The combination of nonhuman primates (NHPs) with the state‐of‐the‐art molecular imaging technologies allows for within‐subject longitudinal research aiming at gaining new insights into human normal and disease conditions and provides an ideal foundation for future translational studies of new diagnostic tools, medical interventions, and therapies. However, radiation dose estimations for nonhuman primates from molecular imaging probes are lacking and are difficult to perform experimentally. The aim of this work is to construct age‐dependent NHP computational model series to estimate the absorbed dose to NHP specimens in common molecular imaging procedures.

中文翻译:

非人类灵长类动物计算模型中常见PET放射性核素和脑放射性示踪剂的年龄依赖性剂量计算。

非人类灵长类动物(NHPs)与最新的分子成像技术相结合,可以进行受试者内部纵向研究,以期获得对人类正常和疾病状况的新见解,并为未来的新诊断学转化研究提供理想的基础工具,医疗干预和疗法。然而,缺乏分子成像探针对非人类灵长类动物的辐射剂量估计,并且难以通过实验进行。这项工作的目的是构建与年龄有关的NHP计算模型系列,以估算常见分子成像程序中NHP标本的吸收剂量。
更新日期:2020-06-15
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