Ramanand et al. perform the first high-resolution 3D genome mapping via ChIA-PET to capture RNAPII-associated chromatin interactions in normal prostate epithelial and prostate cancer cells. They describe how genetics, epigenetics, and the 3D genome architecture are coordinated in the aberrant gene expression that drives prostate cancer development.

中文翻译：

---

通过3D基因组图谱揭开癌症病因的神秘面纱。

Ramanand等。通过ChIA-PET进行第一个高分辨率3D基因组作图，以捕获正常前列腺上皮细胞和前列腺癌细胞中与RNAPII相关的染色质相互作用。他们描述了遗传，表观遗传学和3D基因组架构如何在驱动前列腺癌发展的异常基因表达中进行协调。