Ankylosing spondylitis (AS) is a highly heritable, inflammatory rheumatic disease, characterized by inflammation of the spine and the sacroiliac joints. Although some genes are reportedly associated with this disease, the pathogenesis of AS remains largely unknown. In this study, the peripheral blood mononuclear cells of a patient with AS were reprogrammed to induced pluripotent stem cells (iPSCs) using transgene-free, episomal plasmid vectors. The established iPSC line was validated by multiple methods and demonstrated typical characteristics of embryonic stem cells. This cell line (SHFDi001-A) may be beneficial in disease modeling and related research.

强直性脊柱炎（AS）是一种高度遗传的炎性风湿性疾病，其特征在于脊柱和and关节发炎。尽管据报道某些基因与该疾病有关，但AS的发病机理仍是未知的。在这项研究中，使用无转基因游离型质粒载体，将AS患者的外周血单核细胞重编程为诱导性多能干细胞（iPSC）。建立的iPSC品系通过多种方法验证，并证明了胚胎干细胞的典型特征。此细胞系（SHFDi001-A）在疾病建模和相关研究中可能是有益的。