Abstract In the present paper, hollow hydroxyapatite/polydopamine/gold nanorods (H-HAP/PDA/AuNRs) hybrid microcapsules was prepared for multi-responsive drug delivery via self-assembly method. PDA/AuNRs hybrid shell was employed to obstruct the initial burst drug release and endow the hybrid vehicle with superior photothermal conversion capacity, robust photothermal stability and brilliant near-infrared (NIR)-responsive delivery property. Moreover, due to the mesoporous structure of H-HAP as well as the strong mutual adsorption between PDA and drug, H-HAP/PDA/AuNRs exhibited excellent drug loading efficiency (95.6%). The drug release results demonstrated that the hybrid vehicle possessed distinct pH-/NIR- dual responsiveness, which due to the disintegration of HAP/PDA matrix in acid condition and the synergistically enhanced NIR responsiveness of PDA/AuNRs. Furthermore, cell viability results demonstrated that H-HAP/PDA/AuNRs exhibited outstanding biocompatibility and low bio-toxicity. Thus, the as-prepared H-HAP/PDA/AuNRs hybrid microcapsules hold great promise as novel smart drug carriers for remotely controllable drug delivery.

中文翻译：

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金纳米棒/聚多巴胺封端的中空羟基磷灰石微胶囊作为可远程控制的多功能给药平台

摘要 本文通过自组装方法制备了空心羟基磷灰石/聚多巴胺/金纳米棒（H-HAP/PDA/AuNRs）杂化微胶囊，用于多响应药物递送。PDA/AuNRs 混合壳被用来阻止初始爆发式药物释放，并使混合动力车辆具有优异的光热转换能力、强大的光热稳定性和出色的近红外 (NIR) 响应传递特性。此外，由于 H-HAP 的介孔结构以及 PDA 与药物之间的强相互作用，H-HAP/PDA/AuNRs 表现出优异的载药效率（95.6%）。药物释放结果表明，混合载体具有明显的 pH-/NIR-双重响应能力，这是由于 HAP/PDA 基质在酸性条件下的分解和 PDA/AuNRs 的 NIR 响应性协同增强。此外，细胞活力结果表明 H-HAP/PDA/AuNRs 表现出出色的生物相容性和低生物毒性。因此，所制备的 H-HAP/PDA/AuNRs 混合微胶囊作为用于远程控制药物输送的新型智能药物载体具有广阔的前景。