We have measured the toxicity and genotoxicity of 2-methylfuran, which is formed in foods during thermal processing. The agent was administered by oral gavage to male Sprague-Dawley rats, daily for 28 days, before performing general toxicology analysis and the following genotoxicity tests: comet assay (peripheral blood, liver); Pig-a gene mutation assay (peripheral blood); micronucleus test (peripheral blood, bone marrow). Liver was the primary target organ; histological changes (oval cell hyperplasia) were observed but without significant changes in serum enzyme markers. For hepatotoxicity, the no-observed-adverse-effect level was 5 mg/kg bw/d. Histopathological changes were also seen in the bone marrow. Genotoxicity assays were uniformly negative.

我们测量了食品在热处理过程中形成的 2-甲基呋喃的毒性和遗传毒性。在进行一般毒理学分析和以下基因毒性试验之前，通过对雄性 Sprague-Dawley 大鼠进行口服管饲法，每天给予该药剂 28 天：彗星试验（外周血，肝脏）；猪-a基因突变检测（外周血）；微核试验（外周血、骨髓）。肝脏是主要的靶器官；观察到组织学变化（卵圆形细胞增生），但血清酶标记物没有显着变化。对于肝毒性，未观察到的副作用水平为 5 毫克/千克体重/天。在骨髓中也观察到组织病理学变化。基因毒性试验均呈阴性。