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A novel electrochemical biosensor for the determination of dopamine and ascorbic acid based on graphene oxide /poly(aniline-co-thionine) nanocomposite
Journal of Electroanalytical Chemistry ( IF 4.5 ) Pub Date : 2020-09-01 , DOI: 10.1016/j.jelechem.2020.114352
Nan-nan Song , Yin-zhu Wang , Xue-yun Yang , Hui-long Zong , Ya-xian Chen , Zhen Ma , Chuan-xiang Chen

Abstract In this paper, we fabricated a sensitive and stable ascorbic acid (AA) and dopamine (DA) amperometric biosensor using nanobiocomposite derived from poly(aniline-co-thionine) (P(ANI-co-THI)) modified graphene oxide (GO). A simple one-step electrochemical deposition method was used to deposit P(ANI-co-THI) on GO/GCE to prepare graphene oxide/poly(aniline-co-thionine) (GO/P(ANI-co-THI)) composite modified electrode. The GO/P(ANI-co-THI) nanocomposite was characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and UV–Vis spectroscopy. The electrochemical performance was evaluated by differential pulse voltammetry (DPV) in 0.2 M PBS solution (pH = 7). The modified electrode displayed excellent electrocatalytic activity toward AA (typically at − 0.09 V vs. SCE) and DA (typically at 0.176 V vs. SCE) and the oxidation peak current of AA and DA increased to 2.9 and 2.6-times of that at GO/GCE, respectively. Response to DA was linear in the concentration range of 0.002 to 0.5 mM with a detection limit of 2 μM. Response to AA was linear in the concentration range of 0.5 to 5 mM with a detection limit of 242 μM. Furthermore, the GO/P(ANI-co-THI)-based electrochemical sensor also exhibited high selectivity, good reproducibility and stability,wide detection range and low detection line.

中文翻译:

基于氧化石墨烯/聚(苯胺-共-硫氨酸)纳米复合材料的新型电化学生物传感器测定多巴胺和抗坏血酸

摘要 在本文中,我们使用源自聚(苯胺-共-硫氨酸)(P(ANI-co-THI))修饰的氧化石墨烯(GO)的纳米生物复合材料制造了一种灵敏且稳定的抗坏血酸(AA)和多巴胺(DA)电流生物传感器。 )。一种简单的一步电化学沉积方法在GO/GCE上沉积P(ANI-co-THI)以制备氧化石墨烯/聚(苯胺-co-硫氨酸)(GO/P(ANI-co-THI))复合材料修饰电极。GO/P(ANI-co-THI)纳米复合材料通过扫描电子显微镜(SEM)、傅里叶变换红外光谱(FTIR)和紫外-可见光谱进行表征。通过差分脉冲伏安法 (DPV) 在 0.2 M PBS 溶液 (pH = 7) 中评估电化学性能。修饰的电极对 AA(通常在 - 0.09 V vs. SCE)和 DA(通常在 0.176 V vs. SCE)表现出优异的电催化活性。SCE) 和 AA 和 DA 的氧化峰值电流分别增加到 GO/GCE 的 2.9 和 2.6 倍。对 DA 的响应在 0.002 至 0.5 mM 的浓度范围内呈线性,检测限为 2 μM。对 AA 的响应在 0.5 至 5 mM 的浓度范围内呈线性,检测限为 242 μM。此外,基于GO/P(ANI-co-THI)的电化学传感器还表现出高选择性、良好的重现性和稳定性、宽检测范围和低检测线。
更新日期:2020-09-01
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