Abstract Using multiple detection electrodes to acquire a signal with a frequency that is a multiple of the cyclotron frequency offers the ability to decrease the analysis time of Fourier transform ion cyclotron resonance mass spectrometry while maintaining high resolving power by measuring the ion cloud-induced image current several times per cyclotron orbit. However, there are inherent difficulties associated with this method, including generation of unwanted spectral peaks and loss of sensitivity. Simulations of the image-charge produced by a population of ions, with multiple-frequency detection, provide insight into the origin of these problems, from which methods for their mitigation can be deduced. A particle-in-cell simulation with an image-charge calculator is used to examine the effect of magnetron offset and excitation radius on the measured signals for Nω detection. Simulated transients of an IgG-sized protein (150 kDa) at 1ω and 10ω detection are compared and beat patterns for Nω detection are examined. The amplitude of subharmonic peaks is found to increase significantly with the radius of the magnetron component of the ions’ orbit.

中文翻译：

---

在 FTICR 质谱中使用多个检测电极模拟 nw 测量

摘要 使用多个检测电极来获取频率为回旋频率倍数的信号能够减少傅立叶变换离子回旋共振质谱的分析时间，同时通过测量离子云感应镜像电流保持高分辨率每个回旋加速器轨道数次。然而，这种方法存在固有的困难，包括产生不需要的光谱峰和灵敏度损失。通过多频率检测对由一群离子产生的镜像电荷进行模拟，可以深入了解这些问题的根源，从中可以推断出缓解这些问题的方法。带有镜像电荷计算器的细胞内粒子模拟用于检查磁控管偏移和激发半径对 Nω 检测测量信号的影响。比较了 1ω 和 10ω 检测时 IgG 大小的蛋白质 (150 kDa) 的模拟瞬变，并检查了 Nω 检测的节拍模式。发现次谐波峰的幅度随着离子轨道的磁控管组件的半径而显着增加。