The regulatory mechanisms controlling natural killer (NK) cells in the tumor microenvironment remain unknown. In this issue, Ni. et al. provide evidence that the transcription factor HIF-1α acts as a key negative regulator of NK cell metabolic fitness in the tumor microenvironment that critically impedes NK cell anti-tumor immune responses.

中文翻译：

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凭空产生自然杀手。

在肿瘤微环境中控制自然杀伤（NK）细胞的调节机制仍然未知。在这个问题上，倪。等。提供的证据表明，转录因子HIF-1α在肿瘤微环境中充当NK细胞代谢适应性的关键负调控因子，从而严重阻碍NK细胞的抗肿瘤免疫反应。