当前位置: X-MOL 学术Drug. Discov. Today › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Applications of magnetotactic bacteria and magnetosome for cancer treatment: A review emphasizing on practical and mechanistic aspects.
Drug Discovery Today ( IF 7.4 ) Pub Date : 2020-06-16 , DOI: 10.1016/j.drudis.2020.06.010
Edouard Alphandéry 1
Affiliation  

Magnetotactic bacteria (MTB) synthesize iron oxide (Fe3O4) nanoparticles (NPs), called magnetosomes, with large sizes leading to a ferrimagnetic behavior and a stable magnetic moment at physiological temperature, a chain structure that prevents NP aggregation and promotes uniform NP distribution, and a mineral core of magnetite/maghemite composition, which can be stabilized by an organic coating. Such properties can favor magnetosome administration to humans under certain optimized non-toxic conditions of fabrication. In this review, I describe the fabrication methods, physico-chemical properties, and the anti-tumor activity of different types of MTB/magnetosome preparations, highlighting the bio-compatibility and excellent anti-tumor activity of purified non-pyrogenic magnetosome minerals stabilized by a synthetic chemical compound.



中文翻译:

趋磁细菌和磁小体在癌症治疗中的应用:强调实用和机械方面的综述。

趋磁细菌 (MTB) 合成氧化铁 (Fe 3 O 4) 纳米粒子 (NPs),称为磁小体,具有大尺寸导致亚铁磁性行为和生理温度下稳定的磁矩,防止 NP 聚集并促进 NP 分布均匀的链结构,以及磁铁矿/磁赤铁矿组成的矿物核心,可以通过有机涂层稳定。在某些优化的无毒制造条件下,这些特性有利于磁小体对人类的给药。在这篇综述中,我描述了不同类型 MTB/磁小体制剂的制备方法、理化性质和抗肿瘤活性,强调了经纯化的无热原磁小体矿物的生物相容性和优异的抗肿瘤活性。一种合成化合物。

更新日期:2020-08-19
down
wechat
bug