Stimulus-responsive degradable mesoporous organosilica nanoparticles (MONs) have shown great promise as drug carriers via enhancing the efficiency of drug delivery and accelerating the degradation of nanocarriers. However, it remains a great challenge to develop novel light-enabled spatial and temporal degradable MONs with both superior responsiveness for efficient anti-cancer drug delivery and safe exocytosis. We report a novel photo-responsive degradable hollow mesoporous organosilica nanoplatform (HMONs@GOQD). The platform is based on organosilica nanoparticles (HMONs) containing singlet oxygen (1O2)-responsive bridged organoalkoxysilanes and wrapped graphene oxide quantum dots (GOQDs). The unique hollow mesoporous structure of the HMONs guarantees an excellent drug loading and release profile. During light irradiation, 1O2 produced by the GOQDs leads to the degradation of the organosilica nanoparticles, resulting in enhanced local drug release. We carried out in vitro and in vivo experiments using DOX as a model drug; DOX-HMONs@GOQDs exhibited high biocompatibility, accelerated degradation, and superior therapeutic efficacy during light irradiation, indicating a promising platform for clinical cancer therapy.

中文翻译：

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用于药物递送的光响应性可降解空心中孔有机二氧化硅纳米平台。

刺激响应的可降解介孔有机二氧化硅纳米颗粒（MONs）通过提高药物输送效率和加速纳米载体的降解，显示出作为药物载体的巨大希望。然而，开发新型的具有光响应能力的时空可降解的MONs仍然是一个巨大的挑战，这些MONs具有对有效的抗癌药物递送和安全的胞吐作用都具有出色的响应能力。我们报告了一种新型的光响应可降解空心中孔有机硅纳米平台（HMONs @ GOQD）。该平台基于包含单线态氧（1O2）响应的桥接有机烷氧基硅烷和包裹的氧化石墨烯量子点（GOQD）的有机硅纳米粒子（HMON）。HMONs独特的中空介孔结构确保了出色的药物加载和释放特性。在光照期间，GOQD产生的1O2导致有机硅纳米粒子的降解，导致局部药物释放增强。我们使用DOX作为模型药物进行了体外和体内实验；DOX-HMONs @ GOQDs在光照射下表现出高生物相容性，加速降解和优异的治疗功效，为临床癌症治疗提供了有希望的平台。