To investigate the metabolite changes in the frontal lobe of the end-stage renal disease (ESRD) patients with depression using proton magnetic resonance spectroscopy (1H-MRS). All subjects were divided into three groups: ESRD patients with depression (30 cases), ESRD patients without depression (27 cases) and 32 normal subjects. ESRD with depression patients were further divided into two groups according to the severity of depression: 14 cases of ESRD with severe depression group (Hamilton Depression Rating Scale (HAMD) score ≥ 35) and 16 cases of ESRD with mild to moderate depression group (20 ≤ HAMD score<35). 1H-MRS was used in brain regions of all subjects to measure N-acetylaspartate/creatine (NAA/Cr), choline-containing compounds/creatine (Cho/Cr) and myo-inositol/creatine (MI/Cr) ratios of the frontal lobe. Correlations between the metabolite ratio and HAMD score as well as clinical finding were confirmed, respectively. ESRD patients with depression showed lower NAA/Cr ratio and higher Cho/Cr ratio compared with ESRD patients without depression and normal subjects. NAA/Cr ratio was negatively correlated with the HAMD score. Cho/Cr ratio was positively correlated with the HAMD score. There were positive correlations between NAA/Cr ratio and blood urea notrogen (BUN) as well as creatinine (CRE) concentration, respectively. There was a negative correlation between Cho/Cr ratio and sodium concentration. The Cho/Cr ratio was positively correlated with the potassium concentration. MR spectroscopy identified some metabolite changes in ESRD patients with depression.

中文翻译：

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1H-MRS在终末期肾病伴抑郁症中的应用[J].

使用质子磁共振波谱（1H-MRS）研究终末期肾病（ESRD）抑郁症患者额叶代谢物的变化。将所有受试者分为三组：ESRD 抑郁症患者（30 例）、ESRD 无抑郁症患者（27 例）和 32 名正常人。ESRD合并抑郁症患者根据抑郁的严重程度进一步分为两组：14例ESRD合并重度抑郁组（汉密尔顿抑郁量表（HAMD）评分≥35）和16例ESRD合并轻中度抑郁组（20 ≤ HAMD 得分<35)。1H-MRS 用于所有受试者的大脑区域，以测量 N-乙酰天冬氨酸/肌酸 (NAA/Cr)、含胆碱化合物/肌酸 (Cho/Cr) 和肌醇/肌酸 (MI/Cr) 比值叶。分别证实了代谢物比率和 HAMD 评分以及临床发现之间的相关性。与没有抑郁症的 ESRD 患者和正常受试者相比，有抑郁症的 ESRD 患者显示出较低的 NAA/Cr 比值和较高的 Cho/Cr 比值。NAA/Cr 比值与 HAMD 评分呈负相关。Cho/Cr 比值与 HAMD 评分呈正相关。NAA/Cr 比值分别与血尿素氮 (BUN) 和肌酐 (CRE) 浓度呈正相关。Cho/Cr 比值与钠浓度之间存在负相关。Cho/Cr 比值与钾浓度呈正相关。磁共振波谱确定了患有抑郁症的 ESRD 患者的一些代谢物变化。与没有抑郁症的 ESRD 患者和正常受试者相比，有抑郁症的 ESRD 患者显示出较低的 NAA/Cr 比值和较高的 Cho/Cr 比值。NAA/Cr 比值与 HAMD 评分呈负相关。Cho/Cr 比值与 HAMD 评分呈正相关。NAA/Cr 比值分别与血尿素氮 (BUN) 和肌酐 (CRE) 浓度呈正相关。Cho/Cr 比值与钠浓度之间存在负相关。Cho/Cr 比值与钾浓度呈正相关。磁共振波谱确定了患有抑郁症的 ESRD 患者的一些代谢物变化。与没有抑郁症的 ESRD 患者和正常受试者相比，有抑郁症的 ESRD 患者显示出较低的 NAA/Cr 比值和较高的 Cho/Cr 比值。NAA/Cr 比值与 HAMD 评分呈负相关。Cho/Cr 比值与 HAMD 评分呈正相关。NAA/Cr 比值分别与血尿素氮 (BUN) 和肌酐 (CRE) 浓度呈正相关。Cho/Cr 比值与钠浓度之间存在负相关。Cho/Cr 比值与钾浓度呈正相关。磁共振波谱确定了患有抑郁症的 ESRD 患者的一些代谢物变化。Cho/Cr 比值与 HAMD 评分呈正相关。NAA/Cr 比值分别与血尿素氮 (BUN) 和肌酐 (CRE) 浓度呈正相关。Cho/Cr 比值与钠浓度之间存在负相关。Cho/Cr 比值与钾浓度呈正相关。磁共振波谱确定了患有抑郁症的 ESRD 患者的一些代谢物变化。Cho/Cr 比值与 HAMD 评分呈正相关。NAA/Cr 比值分别与血尿素氮 (BUN) 和肌酐 (CRE) 浓度呈正相关。Cho/Cr 比值与钠浓度之间存在负相关。Cho/Cr 比值与钾浓度呈正相关。磁共振波谱确定了患有抑郁症的 ESRD 患者的一些代谢物变化。