Nanozymes are a new generation of artificial enzymes that address the limitations of natural enzymes, with numerous reports on the development of high performance nanozymes for various applications. Herein, the phase regulation of network-like MoSe₂ from the metal 1T phase to semiconductor 2H phase was achieved under different reaction conditions by a facile but efficient microwave-assisted solvothermal method. The coexisting 1T/2H-MoSe₂ with edge enriched and defective nanostructures showed great enhancement of the peroxidase-like properties. This high enzymatic activity may arise from optimized active sites of 1T/2H-MoSe₂, effectively leading to a rapid charge transfer within the substrate. In addition, chitosan functionalization not only greatly improves the dispersion stability of MoSe₂, but also significantly increases its peroxidase-like activity, probably due to its enhanced affinity to hydrogen peroxide (H₂O₂). Based on these results we have established a highly sensitive colorimetric assay for the detection of H₂O₂ and glucose in human serum.

中文翻译：

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从2H到1T连续调节MoSe2的相，以优化过氧化物酶样催化。

纳米酶是解决天然酶的局限性的新一代人工酶，有关为各种应用开发高性能纳米酶的报道很多。在此，通过简便而有效的微波辅助溶剂热法，在不同的反应条件下，实现了从金属1T相到半导体2H相的网络状MoSe ₂的相调节。具有边缘富集和有缺陷的纳米结构的共存的1T / 2H-MoSe ₂显示出过氧化物酶样性质的极大增强。这种高酶活性可能来自1T / 2H-MoSe _2的优化活性位点，有效导致基板内电荷的快速转移。此外，壳聚糖官能化不仅大大提高了MoSe ₂的分散稳定性，而且还显着提高了其过氧化物酶样活性，这可能是由于其对过氧化氢（H ₂ O ₂）的亲和力增强。基于这些结果，我们建立了一种高灵敏度的比色测定法，用于检测人血清中的H ₂ O ₂和葡萄糖。