Mesoporous silica particles (MSPs) enhance the release kinetics of poorly soluble compound probucol (PB) under the influence of a pore-blocking protein corona, prepared with lysozyme protein adsorption. In vivo oral administration experiments show a prolongation in the time to reach maximum systemic concentration and half-life of PB released from the lysozyme-MSP complex in comparison to the MSP alone. Specific hard protein corona complexes can act as functional diffusion barriers for the controlled release of drugs from MSP based formulations.

中文翻译：

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一种溶菌酶电晕复合物，用于从中孔二氧化硅颗粒中控制普罗布考的药代动力学释放。

介孔二氧化硅颗粒（MSP）在溶孔酶蛋白吸附下制备的孔封闭蛋白电晕的作用下，提高了难溶性化合物普罗布考（PB）的释放动力学。体内口服实验表明，与单独的MSP相比，溶菌酶-MSP复合物释放的PB达到最大全身浓度和半衰期的时间延长。特定的硬蛋白电晕复合物可充当功能性扩散屏障，以控制药物从基于MSP的制剂中释放出来。