Bacterial infection has been recognized as one of the greatest threats to public health. In view of the continuous increase of bacterial resistance, constructing a collaborative bactericidal platform is a promising strategy to enhance the efficiency of antimicrobial agents. Herein, we report a facile, biocompatible and versatile nano-platform based on positively charged copper manganate nanoflakes (CuMnO₂ NFs), which exhibits intrinsic peroxidase-like catalytic activity and excellent photothermal properties. The CuMnO₂ NFs can bind with negatively charged bacteria via electrostatic interactions, and generate hydroxyl radicals (˙OH) through catalysis involving hydrogen peroxide (H₂O₂) to make bacteria more susceptible to temperature. Introducing near-infrared light generates hyperthermia to fight against bacteria and enhances the peroxidase-like catalytic activity of the CuMnO₂ NFs, thus producing more ˙OH to combat bacteria. The PTT-enhanced ˙OH synergistic antibacterial strategy exerts desirable antibacterial efficiencies of 98.78% and 99.92% against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) at a controlled low temperature (below 50 °C), without damage to healthy tissues. Animal experiments indicate that this synergistic treatment has a better therapeutic effect on S. aureus-infected wounds in mice, compared with either treatment by itself. Therefore, this work holds great promise for developing new synergistic antimicrobial strategies to treat bacterial infections.

中文翻译：

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一种基于锰酸铜纳米片的双功能纳米平台，可通过催化和光热协同效应消除细菌。

细菌感染已被认为是对公共卫生的最大威胁之一。鉴于细菌耐药性的不断增加，构建协同的杀菌平台是提高抗菌剂效率的有前途的策略。在本文中，我们报告了一种基于带正电的锰酸铜纳米薄片（CuMnO ₂ NFs）的便捷，生物相容性和多功能纳米平台，该平台表现出固有的过氧化物酶样催化活性和出色的光热性能。CuMnO ₂ NFs可以通过静电相互作用与带负电荷的细菌结合，并通过涉及过氧化氢（H ₂ O ₂）的催化产生羟基自由基（˙OH）），使细菌更容易受到温度的影响。引入近红外光会产生高温以对抗细菌，并​​增强CuMnO ₂ NFs的过氧化物酶样催化活性，从而产生更多的OH来对抗细菌。PTT增强的˙OH协同抗菌策略可在受控的低温（低于50°C）下对大肠杆菌（E. coli）和金黄色葡萄球菌（S. aureus）产生理想的抗菌效率，分别为98.78％和99.92％健康组织。动物实验表明，这种协同治疗对金黄色葡萄球菌有较好的治疗作用。与任何一种治疗方法相比，小鼠感染伤口的可能性更高。因此，这项工作对于开发治疗细菌感染的新的协同抗菌策略具有广阔的前景。