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A lipidome atlas in MS-DIAL 4.
Nature Biotechnology ( IF 46.9 ) Pub Date : 2020-06-15 , DOI: 10.1038/s41587-020-0531-2
Hiroshi Tsugawa 1, 2 , Kazutaka Ikeda 1, 3 , Mikiko Takahashi 2 , Aya Satoh 2 , Yoshifumi Mori 4 , Haruki Uchino 1, 5 , Nobuyuki Okahashi 1, 6 , Yutaka Yamada 2 , Ipputa Tada 7 , Paolo Bonini 8 , Yasuhiro Higashi 2 , Yozo Okazaki 2, 9 , Zhiwei Zhou 10, 11 , Zheng-Jiang Zhu 10 , Jeremy Koelmel 12, 13 , Tomas Cajka 14 , Oliver Fiehn 15 , Kazuki Saito 2, 16 , Masanori Arita 2, 17 , Makoto Arita 1, 5, 18
Affiliation  

We present Mass Spectrometry-Data Independent Analysis software version 4 (MS-DIAL 4), a comprehensive lipidome atlas with retention time, collision cross-section and tandem mass spectrometry information. We formulated mass spectral fragmentations of lipids across 117 lipid subclasses and included ion mobility tandem mass spectrometry. Using human, murine, algal and plant biological samples, we annotated and semiquantified 8,051 lipids using MS-DIAL 4 with a 1–2% estimated false discovery rate. MS-DIAL 4 helps standardize lipidomics data and discover lipid pathways.



中文翻译:

MS-DIAL中的脂质组图谱4。

我们介绍了质谱数据独立分析软件版本4(MS-DIAL 4),这是一个全面的脂质组图谱,具有保留时间,碰撞截面和串联质谱信息。我们制定了涵盖117个脂质亚类的脂质的质谱碎片化方法,并包括离子淌度串联质谱法。使用人类,鼠类,藻类和植物的生物样品,我们使用MS-DIAL 4注释和半定量了8051种脂质,估计的错误发现率为1-2%。MS-DIAL 4帮助标准化脂质组学数据并发现脂质途径。

更新日期:2020-06-15
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