Inflammatory bowel disease (IBD), a chronic relapsing gastrointestinal inflammatory disease, mainly comprises ulcerative colitis (UC) and Crohn’s disease (CD). Although the mechanisms and pathways of IBD have been widely examined in recent decades, its exact pathogenesis remains unclear. Studies have focused on the discovery of new therapeutic targets and application of precision medicine. Recently, a strong connection between IBD and noncoding RNAs (ncRNAs) has been reported. ncRNAs include microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs). The contributions of lncRNAs and circRNAs in IBD are less well-studied compared with those of miRNAs. However, lncRNAs and circRNAs are likely to drive personalized therapy for IBD. They will enable accurate diagnosis, prognosis, and prediction of therapeutic responses and promote IBD therapy. Herein, we briefly describe the molecular functions of lncRNAs and circRNAs and provide an overview of the current knowledge of the altered expression profiles of lncRNAs and circRNAs in patients with IBD. Further, we discuss how these RNAs are involved in the nosogenesis of IBD and are emerging as biomarkers.

炎症性肠病（IBD）是一种慢性复发性胃肠炎，主要包括溃疡性结肠炎（UC）和克罗恩病（CD）。尽管近几十年来IBD的机制和途径已得到广泛研究，但其确切发病机理仍不清楚。研究集中于发现新的治疗靶点和精密医学的应用。近来，已经报道了IBD和非编码RNA（ncRNA）之间的牢固联系。ncRNA包括microRNA（miRNA），长非编码RNA（lncRNA）和环状RNA（circRNA）。与miRNA相比，在IBD中lncRNA和circRNA的贡献研究较少。但是，lncRNA和circRNA可能会推动针对IBD的个性化治疗。它们将使准确的诊断，预后，和预测治疗反应并促进IBD治疗。本文中，我们简要描述了lncRNA和circRNA的分子功能，并概述了IBD患者中lncRNA和circRNA的表达谱变化的最新知识。此外，我们讨论了这些RNA如何与IBD的发生有关，并正在作为生物标志物出现。