SUMOylation is a post‐translational modification that regulates protein signalling and complex formation by adjusting the conformation or protein–protein interactions of the substrate protein. There is a compelling and rapidly expanding body of evidence that, in addition to SUMOylation of nuclear proteins, SUMOylation of extranuclear proteins contributes to the control of neuronal development, neuronal stress responses and synaptic transmission and plasticity. In this brief review we provide an update of recent developments in the identification of synaptic and synapse‐associated SUMO target proteins and discuss the cell biological and functional implications of these discoveries.

中文翻译：

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突触和突触相关蛋白的 SUMOylation：更新

SUMOylation 是一种翻译后修饰，通过调整底物蛋白的构象或蛋白质-蛋白质相互作用来调节蛋白质信号和复合物形成。有大量令人信服且迅速扩大的证据表明，除了核蛋白的 SUMO 化之外，核外蛋白的 SUMO 化有助于控制神经元发育、神经元应激反应以及突触传递和可塑性。在这篇简短的综述中，我们提供了突触和突触相关 SUMO 靶蛋白鉴定的最新进展，并讨论了这些发现的细胞生物学和功能意义。