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Adenoviruses – Infection, pathogenesis and therapy
FEBS Letters ( IF 3.5 ) Pub Date : 2020-06-01 , DOI: 10.1002/1873-3468.13849
Urs F Greber 1
Affiliation  

Both well‐known and emerging viruses increasingly affect humans and cause disease, sometimes with devastating impact on society. The viruses present in the biosphere are the top predators in the life chain, virtually without enemies, except perhaps the immune system, and harsh environmental physicochemical conditions restricting their dissemination. We know a lot about viruses, but do we know enough? This series of reviews is dedicated to adenoviruses (AdVs), a family of nonenveloped DNA viruses occurring in vertebrates, including humans. AdVs have been the focus of intense research for more than 67 years. Besides causing disease, they have immensely contributed to the advance of life sciences and medicine over the past decades. Recently, AdVs have been widely used as vehicles in gene therapy and vaccination. They continue to provide fundamental insights into virus–host interactions in cells, tissues and organisms, as well as systems and metabolic networks. This special issue of FEBS Letters presents a unique collection of 23 state‐of‐the‐art review articles by leading adenovirologists. In this prelude, I present the chapters, which provide a solid basis for further exploring the rich heritage in adenovirus molecular cell biology, structural biology, genetics, immunology, gene therapy and epidemiology. I conclude with an essential discussion of six blind spots in adenovirology.

中文翻译:

腺病毒——感染、发病机制和治疗

众所周知的和新出现的病毒越来越多地影响人类并引起疾病,有时对社会造成破坏性影响。生物圈中存在的病毒是生命链中的顶级捕食者,几乎没有敌人,除了免疫系统和限制其传播的恶劣环境物理化学条件。我们对病毒了解很多,但我们了解的足够多吗?这一系列评论专门针对腺病毒 (AdVs),这是一种发生在包括人类在内的脊椎动物中的无包膜 DNA 病毒家族。67 多年来,广告一直是深入研究的焦点。除了引起疾病外,在过去的几十年里,它们还为生命科学和医学的进步做出了巨大贡献。最近,AdVs 已被广泛用作基因治疗和疫苗接种的载体。他们继续为细胞、组织和生物体中的病毒-宿主相互作用以及系统和代谢网络提供基本见解。本期 FEBS 快报特刊收录了由领先的腺病毒学家撰写的 23 篇最先进的评论文章。在这序曲中,我介绍了各个章节,这些章节为进一步探索腺病毒分子细胞生物学、结构生物学、遗传学、免疫学、基因治疗和流行病学的丰富遗产奠定了坚实的基础。最后,我对腺病毒学中的六个盲点进行了重要讨论。我介绍的章节为进一步探索腺病毒分子细胞生物学、结构生物学、遗传学、免疫学、基因治疗和流行病学的丰富遗产奠定了坚实的基础。最后,我对腺病毒学中的六个盲点进行了重要讨论。我介绍的章节为进一步探索腺病毒分子细胞生物学、结构生物学、遗传学、免疫学、基因治疗和流行病学的丰富遗产奠定了坚实的基础。最后,我对腺病毒学中的六个盲点进行了重要讨论。
更新日期:2020-06-01
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