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Analytical approaches applied to the analysis of apprehended formulations of anabolic androgenic steroids.
Drug Testing and Analysis ( IF 2.9 ) Pub Date : 2020-06-28 , DOI: 10.1002/dta.2877
Lucas M Berneira 1 , Caroline C da Silva 1 , Luan F Passos 1 , Tais Poletti 1 , Marco A Z Dos Santos 1 , Claudio M P de Pereira 1
Affiliation  

Anabolic androgenic steroids (AASs) comprise a class of synthetic androgens resulting from chemical modifications of testosterone, known for their illicit consumption, which can result inextensive side effects. Extraction procedures applied to the analysis of their formulations are still limited to a few methodologies, despite the increasing numbers of confiscations of AASs. In this sense, the aims of this work were to evaluate the extraction of active ingredients from formulations of anabolic agents using solid‐liquid or liquid‐iquid, ultrasonic bath, ultrasonicprobe, and microwave‐assisted extraction. The results indicated that the extraction procedures influenced the detected concentration of AASs, as the use of ultrasonic probe and microwave irradiation increased the overall extraction of anabolic agents compared with solid‐liquid, liquid‐liquid, and ultrasonic bath. Regarding oxymetholone, for instance, the microwave‐assisted extraction and ultrasonic probe extracted, respectively, 37.46 ± 1.36 and 35.69 ± 0.98 mg/tablet, while solid‐liquid extracted 29.63 ± 0.40 mg/tablet of the activeingredient. Therefore, alternative methods such as microwave‐assisted extraction or theultrasonic probe could be used for the analysis of formulations of AASs assisting with the identification of illicit and toxic components.

中文翻译:

应用于分析合成代谢雄激素类固醇制剂的分析方法。

合成代谢雄性类固醇 (AAS) 包括一类由睾酮化学修饰产生的合成雄激素,因其非法消费而闻名,这可能会导致广泛的副作用。尽管 AAS 没收的数量越来越多,但用于分析其配方的提取程序仍仅限于少数方法。从这个意义上说,这项工作的目的是评估使用固-液或液-液、超声波浴、超声波探针和微波辅助提取从合成代谢剂制剂中提取活性成分的情况。结果表明,提取程序影响 AAS 的检测浓度,因为与固液相比,使用超声波探头和微波辐射增加了合成代谢剂的整体提取,液-液和超声波浴。以羟甲烯龙为例,微波辅助提取和超声波探头提取的活性成分分别为 37.46±1.36 和 35.69±0.98 毫克/片,而固液提取的活性成分为 29.63±0.40 毫克/片。因此,微波辅助提取或超声波探针等替代方法可用于分析 AAS 的配方,帮助识别非法和有毒成分。
更新日期:2020-06-28
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