Mediated electron‐transfer sensors provide a practical means of detection for species for whom direct electron‐transfer sensors are impractical. Through the use of numerical simulation, the design and optimisation of mediated electron‐transfer sensors are presented in this work where we specifically consider the mediation as an irreversible process. Comparison is made between sensors employing the mediator as an adsorbed monolayer on the electrode's surface and sensors employing it as a soluble additive to the sample, with the former being concluded as preferable due to improved detection limits and practicality. Studies are performed for the optimisation of the electrode radius, mediating chemical rate constant and scan rate, with consideration also given to the capacitive current. Triangular and semi‐circular sweep voltammetry are compared in the context of mediating electron‐transfer sensor design. It is concluded that competition between the Faradaic and capacitive currents is a primary limitation for this technique.

中文翻译：

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使用模拟指导基于介电子转移的安培电化学传感器的设计

介导的电子传输传感器为不适合使用直接电子传输传感器的物种提供了一种实用的检测方法。通过使用数值模拟，在这项工作中介绍了介导的电子转移传感器的设计和优化，我们专门将调解视为不可逆的过程。在使用介体作为电极表面上吸附单层的传感器与将其作为样品的可溶性添加剂的传感器之间进行了比较，由于提高了检测限和实用性，前者被认为是可取的。进行了研究，以优化电极半径，介导化学速率常数和扫描速率，同时还考虑了电容电流。在介导电子传输传感器设计的背景下，比较了三角形和半圆形扫描伏安法。结论是，法拉第电流和电容电流之间的竞争是该技术的主要限制。